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SEC63 homolog, protein translocation regulator

Summary

Gene Symbol

SEC63

Organism

Homo sapiens (human)

External Links

NCBI Gene

11231

PubChem

11231

Alliance of Genome Resources

HGNC:21082

Annotation

Keyword

Chaperone
Coiled coil
Disease variant
Endoplasmic reticulum
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z5M1
Q9UGP8	DnaJ homolog subfamily C member 23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nitrogen cycle metabolic process	IEA
post-translational protein targeting to membrane, translocation	IMP	29719251
post-translational protein targeting to endoplasmic reticulum membrane	IBA IMP	22375059
SRP-dependent cotranslational protein targeting to membrane	IBA IMP	22375059
liver development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitrogen cycle metabolic process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IDA	22375059
Sec62/Sec63 complex	IBA
endoplasmic reticulum	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

Sec62/Sec63 complex

endoplasmic reticulum protein-containing complex [inference]

Sec62/Sec63 complex

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21251912 26871637
protein transmembrane transporter activity	IBA
signaling receptor activity	TAS	10799540
RNA binding	HDA	22658674

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

macromolecule transmembrane transporter activity [inference]

protein transmembrane transporter activity

protein transporter activity [inference]

protein transmembrane transporter activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sec63

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SRP-dependent cotranslational protein targeting to membrane
post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 5** entries
InterPro
C2 domain superfamily
Chaperone J-domain superfamily
DnaJ domain
Immunoglobulin E-set
Sec63 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050770	polycystic liver disease	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38819		FB:FBgn0035771
Mus musculus	140740		MGI:2155302	MOUSE00766
Caenorhabditis elegans	173278		WB:WBGene00001047
Rattus norvegicus	309858		RGD:1304984	RATNO22002
Danio rerio	436861		ZFIN:ZDB-GENE-040718-328	DANRE18673
Xenopus laevis	443902		Xenbase:XB-GENE-17336998
Pan troglodytes	462915	9598_0:001cce		PANTR38805
Xenopus laevis	495416		Xenbase:XB-GENE-989525
Bos taurus	541040			BOVIN35585
Macaca mulatta	698863			MACMU35760

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements