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Guidelines

MIRAGE

ERI1 exoribonuclease family member 2

Summary

Gene Symbol

ERI2

Organism

Homo sapiens (human)

External Links

NCBI Gene

112479

PubChem

112479

Alliance of Genome Resources

HGNC:30541

JoGo

ERI2

TogoVar

ERI2

Annotation

Keyword

3D-structure
Alternative splicing
Exonuclease
Magnesium
Proteomics identification
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
A8K979	Exonuclease domain-containing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

ncRNA processing [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
3'-5'-RNA exonuclease activity	IBA
nucleic acid binding	IEA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ERI1 exoribonuclease 2

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
3'-5'-RNA exonuclease activity
hydrolase activity
metal ion binding
nuclease activity
zinc ion binding

Displaying **all 5** entries
InterPro
ERI-1-like, DEDDh 3'-5' exonuclease domain
Exonuclease, RNase T/DNA polymerase III
Ribonuclease H superfamily
Ribonuclease H-like superfamily
Zinc finger, GRF-type

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025