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prostaglandin D2 receptor 2

Summary

Gene Symbol

PTGDR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

11251

PubChem

11251

Alliance of Genome Resources

HGNC:4502

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5Y4	Chemoattractant receptor-homologous molecule expressed on Th2 cells G-protein coupled receptor 44

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chemotaxis	IDA	11208866
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
positive regulation of G protein-coupled receptor signaling pathway	IEA
neuropeptide signaling pathway	IBA
calcium-mediated signaling	IDA	11208866

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

locomotion [inference]

taxis [inference]

chemotaxis

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of reproductive process [inference]

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA TAS
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 5** entries
GO Term	Evidence Code	PMID
neuropeptide binding	IBA
prostaglandin J receptor activity	IEA
prostaglandin D receptor activity	IBA IDA	11208866
G protein-coupled receptor activity	IDA	11208866
prostaglandin F receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

icosanoid receptor activity [inference]

prostanoid receptor activity [inference]

prostaglandin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Prostaglandin D2 receptor 2

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
inflammatory response
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Formyl peptide receptor-related
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:4483	rhinitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14764		MGI:1330275	MOUSE26178
Rattus norvegicus	309212		RGD:1311986	RATNO15478
Bos taurus	337885			BOVIN23157
Pan troglodytes	466622	9598_0:002f3d		PANTR03046
Canis lupus familiaris	483805			CANLF06215
Macaca mulatta	695853			MACMU10072
Equus caballus	100061935			HORSE05909
Ornithorhynchus anatinus	100091949			ORNAN17758
Oryctolagus cuniculus	100358235			RABIT01455
Cavia porcellus	100379270			CAVPO18858