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prostaglandin D2 receptor 2

Summary

Gene Symbol

PTGDR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

11251

PubChem

11251

Alliance of Genome Resources

HGNC:4502

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5Y4	Chemoattractant receptor-homologous molecule expressed on Th2 cells G-protein coupled receptor 44

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chemotaxis	IDA	11208866
immune response	TAS	9973380
G protein-coupled receptor signaling pathway	IDA	11208866
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
neuropeptide signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

locomotion [inference]

taxis [inference]

chemotaxis

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of reproductive process [inference]

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
prostaglandin J receptor activity	IEA
G protein-coupled receptor activity	IDA	11208866
prostaglandin D receptor activity	IDA	11208866
prostaglandin D receptor activity	IBA
prostaglandin F receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

icosanoid receptor activity [inference]

prostanoid receptor activity [inference]

prostaglandin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Prostaglandin D2 receptor 2

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
inflammatory response
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Formyl peptide receptor-related
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	11251	RGD:1311986
Mus musculus	14764	RGD:1311986	MOUSE26178
Rattus norvegicus	309212	RGD:1311986	RATNO15478
Bos taurus	337885		BOVIN23157
Pan troglodytes	466622		PANTR03046
Canis lupus familiaris	483805		CANLF06215
Macaca mulatta	695853		MACMU10072
Equus caballus	100061935		HORSE05909
Ornithorhynchus anatinus	100091949		ORNAN17758
Oryctolagus cuniculus	100358235		RABIT01455