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alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Summary

Gene Symbol

MGAT4B

Aliases

GnT-Ivb

Organism

Homo sapiens (human)

External Links

NCBI Gene

11282

GGDB ID

gg129

HGNC

7048

mRNA

NM_014275

map

5q35

Protein

NP_055090

OMIM

604561

KEGG Gene ID

hsa:11282

PubChem

11282

Alliance of Genome Resources

HGNC:7048

Annotation

Keyword

Alternative splicing
Coiled coil
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UQ53	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
N-glycan processing	TAS	10372966
viral protein processing	TAS
protein glycosylation	IDA	17006639

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

viral process [inference]

viral protein processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum-Golgi intermediate compartment	IBA
endoplasmic reticulum	IBA
Golgi membrane	TAS
Golgi stack	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA TAS	10372966 17006639
metal ion binding	IEA
acetylglucosaminyltransferase activity	IBA
protein binding	IPI	32296183 32814053 34981577

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000161013

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg129

Gene Symbol

MGAT4B

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G10219AA	G20030CU	17006639
UDP-GlcNAc	G39213VZ	G29011JC	17006639

Displaying **all 6** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G89993FE	G43299SD	17006639
UDP-GlcNAc	G61751GZ	G92024SL	10372966 17006639
UDP-GlcNAc	G10219AA	G20030CU	17006639
UDP-GlcNAc	G39213VZ	G29011JC	17006639
UDP-GlcNAc	G80858MF	G61207RZ	17006639
UDP-GlcNAc	G10133VD	G92022ML	17006639

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G12045WP		17006639

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	XP_220372	XM_220372
Drosophila melanogaster	NP_648721	NM_140464
Mus musculus	NP_666038	NM_145926

KEGG BRITE Database

Orthology

K00738

Name

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05987	2.4.1.145	G39213VZ	G29011JC

Rhea

RHEA:16057

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.145

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:1470	major depressive disorder	DisGeNET
DOID:1595	melancholic depression	DisGeNET
DOID:1596	depressive disorder	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:2848	obsolete melancholia	DisGeNET
DOID:4766	embryoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39608	FB:FBgn0036446
Callorhinchus milii	103188228		CALMI38602
Danio rerio	431727	ZFIN:ZDB-GENE-040704-19	DANRE07696
Ictalurus punctatus	108268579		ICTPU33570
Electrophorus electricus	113584816		ELEEL34427
Salmo trutta	115171006		SALTR111544
Salmo trutta	115205131		SALTR111544
Chrysemys picta bellii	101945192		CHRPI36513
Pseudonaja textilis	113433797		PSETE04274
Meleagris gallopavo	100543731		MELGA04222

GlyTouCan

GlyComb

GlycoPOST

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All Resources

Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements