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carbohydrate sulfotransferase 14

Summary

Gene Symbol

CHST14

Aliases

D4ST-1
HD4ST

Organism

Homo sapiens (human)

External Links

NCBI Gene

113189

GGDB ID

gg040

HGNC

24464

mRNA

NM_130468

map

15q15.1

Protein

NP_569735

OMIM

608429

KEGG Gene ID

hsa:113189

PubChem

113189

Alliance of Genome Resources

HGNC:24464

Annotation

Keyword

Carbohydrate metabolism
Disease variant
Ehlers-Danlos syndrome
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NCH0	Dermatan 4-sulfotransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate biosynthetic process	IEA
dermatan sulfate biosynthetic process	TAS
dermatan sulfate biosynthetic process	IDA	11470797
dermatan sulfate proteoglycan metabolic process	IDA	11470797
dermatan sulfate proteoglycan metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

amino disaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

dermatan sulfate proteoglycan metabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate biosynthetic process

monosaccharide biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

dermatan sulfate biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

dermatan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

dermatan sulfate biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
membrane	NAS	11470797
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acetylgalactosamine 4-O-sulfotransferase activity	TAS
N-acetylgalactosamine 4-O-sulfotransferase activity	IDA	11470797
protein binding	IPI	35156780
sulfotransferase activity	IBA
phosphate ion binding	NAS	11470797

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

N-acetylgalactosamine 4-O-sulfotransferase activity

binding [inference]

protein binding

ion binding [inference]

anion binding [inference]

phosphate ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
proteoglycan biosynthetic process
sulfotransferase activity
transferase activity

Displaying **all 2** entries
InterPro
Carbohydrate sulfotransferase 8-10
Sulfotransferase

Human Protein Atlas

ENSG00000169105

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg040

Gene Symbol

CHST14

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
PAPS	G10271ZL	R	11470797
PAPS	G71793UG	R	11470797

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Mus musculus	NP_082393	NM_028117

KEGG BRITE Database

Orthology

K08105

Name

dermatan 4-sulfotransferase 1 [EC:2.8.2.35]

References

11470797

Rhea

RHEA:48052

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.35

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080736	Ehlers-Danlos syndrome musculocontractural type 1	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **103** in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000009	Functional abnormality of the bladder
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000085	Horseshoe kidney
HP:0000100	Nephrotic syndrome
HP:0000126	Hydronephrosis
HP:0000153	Abnormality of the mouth
HP:0000160	Narrow mouth
HP:0000175	Cleft palate

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:2953	Ehlers-Danlos syndrome, musculocontractural type
OMIM:601776	Ehlers-Danlos syndrome, musculocontractural type 1

PubChem Disease

MedGen Diseases

Ehlers-Danlos syndrome, musculocontractural type 1

OMIM Phenotypes

EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE, 1; EDSMC1

KEGG Diseases

Ehlers-Danlos syndrome musculocontractural type

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	72136	Xenbase:XB-GENE-1008667	MOUSE35990
Xenopus tropicalis	113189	Xenbase:XB-GENE-1008667
Danio rerio	404732	Xenbase:XB-GENE-1008667	DANRE18944
Bos taurus	511245		BOVIN01023
Xenopus tropicalis	691394	Xenbase:XB-GENE-1008667
Macaca mulatta	703115		MACMU42875
Monodelphis domestica	100027325		MONDO02006
Xenopus tropicalis	100496179	Xenbase:XB-GENE-1008667
Sus scrofa	100520059		PIGXX14609
Anolis carolinensis	100563611		ANOCA08269

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements