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alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Summary

Gene Symbol

MGAT4A

Aliases

GnT-4a
GnT-Iva

Organism

Homo sapiens (human)

External Links

NCBI Gene

11320

GGDB ID

gg128

HGNC

7047

mRNA

NM_012214

map

2q12

Protein

NP_036346

OMIM

604623

KEGG Gene ID

hsa:11320

PubChem

11320

Alliance of Genome Resources

HGNC:7047

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UM21	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
N-glycan processing	ISS
glyoxylate metabolic process	ISS
viral protein processing	TAS
protein glycosylation	IDA	17006639

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

viral process [inference]

viral protein processing

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
endoplasmic reticulum-Golgi intermediate compartment	IBA
endoplasmic reticulum	IBA
peroxisome	ISS
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA TAS	17006639
alanine-glyoxylate transaminase activity	ISS
protein homodimerization activity	ISS
metal ion binding	IEA
acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

transferase activity, transferring nitrogenous groups [inference]

transaminase activity [inference]

alanine-glyoxylate transaminase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000071073

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg128

Gene Symbol

MGAT4A

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G10219AA	G20030CU	17006639
UDP-GlcNAc	G39213VZ	G29011JC	17006639

Displaying **all 7** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G80858MF	G61207RZ	17006639 6222042
UDP-GlcNAc	G89993FE	G43299SD	17006639
UDP-GlcNAc	G39213VZ	G29011JC	10024668 17006639 6222042
UDP-GlcNAc	G61751GZ	G92024SL	17006639
UDP-GlcNAc	G10133VD	G92022ML	17006639
UDP-GlcNAc	G27919IH	G03445UI	6222042
UDP-GlcNAc	G10219AA	G20030CU	17006639

Displaying **all 8** entries
Donor	Acceptor	Reference
UDP-GlcNAc	G30159WR	6222042
UDP-GlcNAc	G77252PU	6222042
UDP-GlcNAc	G12045WP	17006639
UDP-GlcNAc	G07483YN	6222042
UDP-GlcNAc	G78059CC	6222042
UDP-GlcNAc	G58667NI	6222042
UDP-GlcNAc	G59471TH	6222042
UDP-GlcNAc	G99858XP	6222042

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	XP_218731	XM_218731
Drosophila melanogaster	NP_648720	NM_140463
Mus musculus	NP_776295	NM_173870

KEGG BRITE Database

Orthology

K00738

Name

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05987	2.4.1.145	G39213VZ	G29011JC

Rhea

RHEA:16057

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.145

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:4766	embryoma	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET Alliance of Genome Resources
DOID:3312	bipolar disorder	DisGeNET
DOID:3590	gestational trophoblastic neoplasm	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:9256	colorectal cancer	DisGeNET
DOID:9351	diabetes mellitus	DisGeNET
DOID:9352	type 2 diabetes mellitus	DisGeNET

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39608	FB:FBgn0036446
Callorhinchus milii	103177135		CALMI12294
Latimeria chalumnae	102348296		LATCH03023
Danio rerio	563038	ZFIN:ZDB-GENE-070912-27
Astyanax mexicanus	103042427		ASTMX09792
Ictalurus punctatus	108266942		ICTPU30584
Electrophorus electricus	113591090		ELEEL46284
Salmo trutta	115155869		SALTR09574
Salmo trutta	115161257		SALTR14758
Gadus morhua	115533027		GADMO31501

GlyTouCan

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GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements