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acid-sensing ion channel 1

Summary

Gene Symbol

Asic1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11419

PubChem

11419

Alliance of Genome Resources

MGI:1194915

Annotation

Keyword

Alternative splicing
Calcium transport
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6NXK8	Acid-sensing ion channel Amiloride-sensitive cation channel 2, neuronal Brain sodium channel 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
behavioral fear response	IMP	25828470
response to amphetamine	IMP	25828470
monoatomic cation transport	IDA	11854527
monoatomic cation transport	IMP	11854527
neurotransmitter secretion	IMP	18094106

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

associative learning

memory

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to abiotic stimulus [inference]

response to pH [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	ISO
Golgi apparatus	IEA
plasma membrane	ISO
plasma membrane	IDA	11854527 21036899
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

dendritic shaft

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

presynapse

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
ion channel activity	ISO
monoatomic ion channel activity	ISO
monoatomic cation channel activity	IDA	11854527
monoatomic cation channel activity	IMP	11854527
protein binding	IPI	18287010 19571134

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic ion-gated channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acid-sensing ion channel, other

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ligand-gated sodium channel activity
monoatomic ion transport
sodium channel activity
sodium ion transmembrane transport

Displaying 1 entry
InterPro
Epithelial sodium channel

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	40	FB:FBgn0065108
Homo sapiens	41	Xenbase:XB-GENE-977699	HUMAN12588
Drosophila melanogaster	6338	FB:FBgn0065109
Drosophila melanogaster	6340	FB:FBgn0065109
Danio rerio	9311	ZFIN:ZDB-GENE-040513-1
Drosophila melanogaster	11418	FB:FBgn0065108
Xenopus tropicalis	11419	Xenbase:XB-GENE-977699
Drosophila melanogaster	20277	FB:FBgn0052792
Drosophila melanogaster	24767	FB:FBgn0034730
Drosophila melanogaster	24768	FB:FBgn0030795