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actin alpha 2, smooth muscle, aorta

Summary

Gene Symbol

Acta2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11475

PubChem

11475

Alliance of Genome Resources

MGI:87909

Annotation

Keyword

ATP-binding
Acetylation
Cytoskeleton
Direct protein sequencing
Hydrolase
Methylation
Muscle protein
Oxidation
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P62737	Alpha-actin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cellular response to transforming growth factor beta stimulus	IEA
vascular associated smooth muscle contraction	IMP	11053242
mesenchyme migration	ISS
positive regulation of ERK1 and ERK2 cascade	IEA ISO
muscle contraction	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

tissue migration [inference]

mesenchyme migration

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

juxtaglomerular apparatus development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular mesangial cell development

mesangial cell development [inference]

glomerular mesangial cell development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of hepatic stellate cell migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of hepatic stellate cell contraction [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of actin filament-based movement [inference]

positive regulation of hepatic stellate cell contraction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of hepatic stellate cell migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration [inference]

positive regulation of hepatic stellate cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

positive regulation of hepatic stellate cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of hepatic stellate cell activation

regulation of biological quality [inference]

regulation of blood pressure

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
filopodium	ISS
lamellipodium	ISS
protein-containing complex	IEA
smooth muscle contractile fiber	IDA	18332105
actin cytoskeleton	IBA IDA ISO	17882221 8616889

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber [inference]

smooth muscle contractile fiber

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber [inference]

smooth muscle contractile fiber

cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

smooth muscle contractile fiber

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein kinase binding	IPI	21307259
ATP binding	IEA
hydrolase activity	IEA
protein binding	IPI	23055941

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

actin, alpha cardiac muscle 1

Functional Category

K: Transcription
T: Signal transduction mechanisms
Z: Cytoskeleton

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 4** entries
InterPro
ATPase, nucleotide binding domain
Actin family
Actin, conserved site
Actin/actin-like conserved site

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050827	rheumatic heart disease	Alliance of Genome Resources
DOID:0081112	Baraitser-Winter syndrome 1	Alliance of Genome Resources
DOID:0110550	autosomal dominant nonsyndromic deafness 20	Alliance of Genome Resources
DOID:10486	intestinal atresia	Alliance of Genome Resources
DOID:13099	Moyamoya disease	Alliance of Genome Resources
DOID:13832	patent ductus arteriosus	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:4977	lymphedema	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **399** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	58			HUMAN55121
Homo sapiens	59		HGNC:130	HUMAN02079
Homo sapiens	70			HUMAN22154
Homo sapiens	72			HUMAN63291
Rattus norvegicus	25365	10116_1:001bd7
Rattus norvegicus	29275	10116_1:00135e
Rattus norvegicus	29437	10116_1:0050bd
Rattus norvegicus	81633	10116_1:000aa4	RGD:621676	RATNO16338
Danio rerio	322509		ZFIN:ZDB-GENE-030131-1229	DANRE03740
Danio rerio	337770			DANRE16157

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External Links

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OrthoDB (Group)

International Collaboration

Acknowledgements