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complement factor D

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11537

PubChem

11537

Alliance of Genome Resources

MGI:87931

Annotation

Keyword

3D-structure
Alternative splicing
Complement alternate pathway
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7ZNS9	Adipsin C3 convertase activator Properdin factor D
P03953	28 kDa adipocyte protein Adipsin C3 convertase activator Properdin factor D
Q3UP47	Adipsin C3 convertase activator Properdin factor D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
vascular associated smooth muscle cell differentiation	IGI	28057640
proteolysis	IEA
complement activation, alternative pathway	IMP	27564415
response to bacterium	IEP	23012479
Notch signaling pathway	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, alternative pathway

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IBA IDA ISO	7592907

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endopeptidase activity	ISO
serine-type endopeptidase activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

complement factor D

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1556	arthus reaction	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1675		HGNC:2771	HUMAN39250
Rattus norvegicus	54249	10116_1:0029d3	RGD:2498	RATNO39515
Xenopus tropicalis	394945		Xenbase:XB-GENE-973605
Sus scrofa	396877			PIGXX19019
Pan troglodytes	455533			PANTR16593
Canis lupus familiaris	485095			CANLF08120
Bos taurus	505647			BOVIN33359
Danio rerio	553553		ZFIN:ZDB-GENE-050522-411
Ornithorhynchus anatinus	791100			ORNAN28574
Ornithorhynchus anatinus	791113			ORNAN28574

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements