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FCH and mu domain containing endocytic adaptor 2

Summary

Gene Symbol

FCHO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

115548

PubChem

115548

Alliance of Genome Resources

HGNC:25180

Annotation

Keyword

3D-structure
Alternative splicing
Coated pit
Coiled coil
Disulfide bond
Endocytosis
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q0JRZ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
clathrin-dependent endocytosis	IBA IMP	20448150 21762413
clathrin coat assembly	IBA IMP	20448150
membrane invagination	ISS
synaptic vesicle endocytosis	IBA
protein localization to plasma membrane	ISS

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

membrane organization [inference]

membrane invagination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
presynapse	IEA
clathrin-coated vesicle	IBA IDA	21762413
presynaptic endocytic zone membrane
plasma membrane	IBA ISS
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

synaptic membrane [inference]

presynaptic endocytic zone membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19380743 21762413 22323290 35271311
phosphatidylinositol-4,5-bisphosphate binding	ISS
phosphatidylinositol binding	ISS
identical protein binding	IEA IPI	17540576
phosphatidylserine binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylinositol binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

F-BAR domain

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin coat assembly
clathrin-dependent endocytosis

Displaying **all 3** entries
InterPro
AH/BAR domain superfamily
Mu homology domain
Muniscin, C-terminal

Ortholog

Displaying entries **51 - 60** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sinocyclocheilus grahami	107596769		SINGR11929
Ictalurus punctatus	108260057		ICTPU22950
Rhinopithecus bieti	108541184		RHIBE07059
Xenopus laevis	108707254	Xenbase:XB-GENE-6486152
Xenopus laevis	108717768	Xenbase:XB-GENE-17346312
Cyprinus carpio carpio	109051608		CYPCA15697
Crocodylus porosus	109308043		CROPO11958
Phascolarctos cinereus	110216524		PHACI12122
Pseudonaja textilis	113447770		PSETE01983
Athene cunicularia	113490352		ATHCN19907