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RAS guanyl releasing protein 4

Summary

Gene Symbol

RASGRP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

115727

PubChem

115727

Alliance of Genome Resources

HGNC:18958

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Cytoplasm
Differentiation
Guanine-nucleotide releasing factor
Lipid-binding
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
myeloid cell differentiation	TAS	11880369
Ras protein signal transduction	IBA
positive regulation of natural killer cell mediated immunity	ISS
phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
antibacterial innate immune response	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antibacterial innate immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

immune response [inference]

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IDA	11880369
plasma membrane	IBA IDA TAS	11880369
cytoplasmic side of plasma membrane	IDA	11956218
nucleoplasm	IDA
cytosol	IDA TAS	11956218

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
diacylglycerol binding	ISS TAS	11880369
guanyl-nucleotide exchange factor activity	IBA IDA	11880369
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

diacylglycerol binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myotubularin-related protein

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	170668		RGD:620476	RATNO18554
Caenorhabditis elegans	179344		WB:WBGene00009100
Mus musculus	233046		MGI:2386851	MOUSE54119
Pan troglodytes	468867	9598_0:004fa9		PANTR18185
Bos taurus	529375			BOVIN11009
Danio rerio	558453		ZFIN:ZDB-GENE-050419-110
Macaca mulatta	719595			MACMU18055
Saccharomyces cerevisiae S288C	850405		SGD:S000000634
Monodelphis domestica	100013191			MONDO23774
Oryctolagus cuniculus	100350559			RABIT10833