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Guidelines

MIRAGE

NUS1 dehydrodolichyl diphosphate synthase subunit

Summary

Gene Symbol

NUS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

116150

PubChem

116150

Alliance of Genome Resources

HGNC:21042

Annotation

Keyword

3D-structure
Angiogenesis
Congenital disorder of glycosylation
Developmental protein
Differentiation
Disease variant
Endoplasmic reticulum
Glycoprotein
Intellectual disability
Lipid metabolism
Magnesium
Metal-binding
Receptor
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96E22	Cis-prenyltransferase subunit NgBR Nogo-B receptor Nuclear undecaprenyl pyrophosphate synthase 1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
positive regulation of blood vessel endothelial cell migration	IMP	28602162
positive regulation of nitric-oxide synthase activity	IMP	28602162

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein mannosylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein mannosylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein mannosylation

mannosylation [inference]

protein mannosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein mannosylation

macromolecule glycosylation [inference]

protein glycosylation

protein mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein mannosylation

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

dolichol metabolic process [inference]

dolichol biosynthetic process

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport [inference]

regulation of intracellular cholesterol transport

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of intracellular lipid transport [inference]

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport [inference]

regulation of intracellular cholesterol transport

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of intracellular lipid transport [inference]

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

vascular endothelial growth factor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

regulation of intracellular sterol transport [inference]

regulation of intracellular cholesterol transport

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS	32817466
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	19723497
endoplasmic reticulum membrane	IBA
dehydrodolichyl diphosphate synthase complex	IDA	28842490

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

dehydrodolichyl diphosphate synthase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
prenyltransferase activity	IDA	25066056
protein binding	IPI	21572394 32817466 33961781
dehydrodolichyl diphosphate synthase activity	IDA	28842490
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity

dehydrodolichyl diphosphate synthase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nus1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
dehydrodolichyl diphosphate synthase activity
dolichol biosynthetic process

Displaying **all 2** entries
InterPro
Decaprenyl diphosphate synthase-like superfamily
Dehydrodolichyl diphosphate synthase complex subunit Nus1

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080227	autosomal dominant intellectual developmental disorder 55	Alliance of Genome Resources
DOID:0080553	congenital disorder of glycosylation Iaa	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Anolis carolinensis	100553689		ANOCA01330
Nomascus leucogenys	100602333		NOMLE27405
Loxodonta africana	100666506		LOXAF20626
Oreochromis niloticus	100691678		ORENI19360
Cavia porcellus	100719005		CAVPO01051
Bos taurus	100849670		BOVIN35470
Otolemur garnettii	100964923		OTOGA12835
Otolemur garnettii	100966126		OTOGA12835
Papio anubis	101009744		PAPAN34100
Saimiri boliviensis boliviensis	101028238		SAIBB30383

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Last updated: April 7, 2025