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transient receptor potential cation channel, subfamily V, member 5

Summary

Gene Symbol

Trpv5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116469

PubChem

116469

Alliance of Genome Resources

RGD:620636

Annotation

Keyword

ANK repeat
Alternative splicing
Calcium channel
Calmodulin-binding
Cell membrane
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JIP0	Calcium transporter 2 Epithelial calcium channel 1 Osm-9-like TRP channel 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion homeostasis	ISO
calcium ion transmembrane transport	IMP ISO	10875938
calcium ion import across plasma membrane	IBA ISO ISS
calcium ion transport into cytosol	IDA	19463684
regulation of urine volume	ISO ISS

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration [inference]

calcium ion transport into cytosol

regulation of body fluid levels [inference]

regulation of urine volume

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IDA ISO	11423563
plasma membrane	IBA IMP ISO ISS	10875938
calcium channel complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calmodulin binding	IEA
metal ion binding	IEA
calcium channel activity	IBA IDA IMP ISO ISS	10875938 19463684

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding [inference]

calmodulin binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

transient receptor potential cation channel subfamily V member 5

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 6** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain
Transient receptor potential cation channel subfamily V member 5/6
Transient receptor potential cation channel subfamily V member 5
Transient receptor potential cation channel subfamily V

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
apical plasma membrane	PMID:11423563

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31621		FB:FBgn0086693
Drosophila melanogaster	39571		FB:FBgn0036414
Homo sapiens	56302		HGNC:3145	HUMAN91786
Caenorhabditis elegans	177506		WB:WBGene00003841
Caenorhabditis elegans	185101		WB:WBGene00003838
Caenorhabditis elegans	188314		WB:WBGene00003839
Mus musculus	194352	10090_1:001f4a	MGI:2429764	MOUSE47500
Takifugu rubripes	446000			TAKRU45870
Bos taurus	524365			BOVIN28631
Macaca mulatta	705218			MACMU30767