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N-glycanase 1

Summary

Gene Symbol

NGLY1

Organism

Hylobates moloch (silvery gibbon)

External Links

NCBI Gene: 116473729
KEGG Gene ID: hmh:116473729
PubChem: 116473729

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein deglycosylation	IEA	30032202
protein quality control for misfolded or incompletely synthesized proteins	IEA	30032202
glycoprotein catabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

glycoprotein metabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein deglycosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

glycoprotein metabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein deglycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

glycoprotein metabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein deglycosylation

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

glycoprotein metabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein deglycosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IEA	30032202
cytosol	IEA	30032202
cytoplasm	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominoidea

Group Name

Transglutaminase-like

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
glycoprotein catabolic process
hydrolase activity
metal ion binding
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
protein quality control for misfolded or incompletely synthesized proteins

Displaying **all 7** entries
InterPro
Galactose-binding-like domain superfamily
PAW domain superfamily
PUB domain
PUB-like domain superfamily
Papain-like cysteine peptidase superfamily
Peptide N glycanase, PAW domain
Transglutaminase-like

KEGG BRITE Database

Orthology

K01456

Name

peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52]

References

Ortholog

Displaying **all 4** entries
Species	Gene ID	OrthoDB
Homo sapiens	55768	9606_0:00292c
Pongo abelii	100438095	9601_0:0011ad
Nomascus leucogenys	100598050	61853_0:000d93
Symphalangus syndactylus	129486105	9590_0:000270