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LDL receptor related protein associated protein 1

Summary

Gene Symbol

Lrpap1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116565

PubChem

116565

Alliance of Genome Resources

RGD:620700

Annotation

Keyword

Coiled coil
Direct protein sequencing
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Lipoprotein
Phosphoprotein
Receptor
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99068	Gp330-binding 45 kDa protein Low density lipoprotein receptor-related protein-associated protein 1
A6IK06

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
biological_process	ND
negative regulation of amyloid-beta clearance	ISO
regulation of receptor-mediated endocytosis	ISO ISS
negative regulation of very-low-density lipoprotein particle clearance	IBA ISO
negative regulation of receptor internalization	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of cellular process [inference]

signal transduction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
Golgi lumen	IEA
Golgi apparatus	ISO ISS
plasma membrane	IBA ISO
endosome	IBA ISO ISS
vesicle	IDA	8223699

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
lipase binding	IBA IPI	16517593
receptor ligand activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

enzyme binding [inference]

lipase binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Alpha-2-macroglobulin receptor-associated protein

Functional Category

I: Lipid transport and metabolism
K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
heparin binding
lipase binding
low-density lipoprotein particle receptor binding
negative regulation of receptor internalization
negative regulation of very-low-density lipoprotein particle clearance
receptor antagonist activity
very-low-density lipoprotein particle receptor binding

Displaying **all 6** entries
InterPro
Alpha-2-macroglobulin RAP, C-terminal
Alpha-2-macroglobulin RAP, domain 2
Alpha-2-macroglobulin RAP, domain 3
Alpha-2-macroglobulin receptor-associated protein, domain 1
Alpha-2-macroglobulin receptor-associated protein
RAP domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
vesicle	PMID:8223699
rough endoplasmic reticulum lumen	PMID:8223699

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11830	myopia	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of **109** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Equus asinus asinus	106842028		EQUAS03809
Marmota marmota marmota	107138902	9994_0:00311b
Sinocyclocheilus grahami	107551171		SINGR01960
Sinocyclocheilus grahami	107556528		SINGR79167
Ictalurus punctatus	108263656		ICTPU26389
Castor canadensis	109687436	51338_0:001bd1
Phascolarctos cinereus	110212212		PHACI02912
Mus caroli	110294840	10089_0:00165e
Mus pahari	110330398	10093_0:0030af
Meriones unguiculatus	110542579	10047_0:0050ab

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements