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neurexin 2

Summary

Gene Symbol

Nrxn2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116595

PubChem

116595

Alliance of Genome Resources

RGD:620211

Annotation

Keyword

Alternative promoter usage
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Glycoprotein
Heparan sulfate
Metal-binding
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q63374	Neurexin II-alpha Neurexin-2-alpha
A0A8I5ZY56

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
synapse assembly	ISO ISS
adult behavior	IEA ISO
biological_process	ND
vocal learning	IEA ISO
presynaptic modulation of chemical synaptic transmission	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

membrane assembly [inference]

postsynaptic membrane assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

postsynaptic membrane assembly

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

behavior [inference]

learning or memory [inference]

learning [inference]

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

neurotransmitter secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

postsynaptic density protein 95 clustering

protein localization to cell junction [inference]

protein localization to synapse [inference]

gephyrin clustering involved in postsynaptic density assembly

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IEA
presynapse	IEA
protein-containing complex	IEA ISO
plasma membrane	IEA
cell projection	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
neuroligin family protein binding	IEA ISO ISS
calcium channel regulator activity	IEA ISO ISS
metal ion binding	IEA
cell adhesion molecule binding	IEA ISO ISS
transmembrane signaling receptor activity	IEA ISO ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

neuroligin family protein binding

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neurexin-2-beta

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying **all 4** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like domain
Laminin G domain
Neurexin/syndecan/glycophorin C

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9379		HGNC:8009	HUMAN06913
Mus musculus	18190	10090_1:00542b	MGI:1096362	MOUSE25563
Drosophila melanogaster	42646		FB:FBgn0038975
Caenorhabditis elegans	179503		WB:WBGene00007799
Pan troglodytes	451297			PANTR03311
Canis lupus familiaris	483760			CANLF06098
Danio rerio	558326		ZFIN:ZDB-GENE-070206-5
Macaca mulatta	574175			MACMU11559
Equus caballus	100055880			HORSE05219
Papio anubis	100137468			PAPAN06183