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aldehyde dehydrogenase 2, mitochondrial

Summary

Gene Symbol

Aldh2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11669

PubChem

11669

Alliance of Genome Resources

MGI:99600

Annotation

Keyword

Acetylation
Direct protein sequencing
Mitochondrion
NAD
Oxidoreductase
Proteomics identification
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0G2JEU1	ALDH class 2 ALDH-E2
Q544B1	ALDH class 2 ALDH-E2
P47738	AHD-M1 ALDH class 2 ALDH-E2 ALDHI

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ethanol catabolic process	IEA
acetaldehyde metabolic process	ISO
intrinsic apoptotic signaling pathway in response to oxidative stress	ISO
nitroglycerin metabolic process	ISS
negative regulation of apoptotic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitroglycerin metabolic process

catabolic process [inference]

cellular catabolic process [inference]

aldehyde catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

nitroglycerin metabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde

multicellular organismal process [inference]

behavior [inference]

adult behavior [inference]

behavioral response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of reactive oxygen species metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of serotonin biosynthetic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of reactive oxygen species metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	HDA	14651853 18614015
mitochondrial matrix	ISO
mitochondrial matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase (NAD+) activity	ISS
aldehyde dehydrogenase (NAD+) activity	ISO
aldehyde dehydrogenase (NAD+) activity	IBA
protein binding	IPI	21720390
phenylacetaldehyde dehydrogenase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

phenylacetaldehyde dehydrogenase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

carboxylesterase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

NADH binding

ion binding [inference]

anion binding [inference]

NADH binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

NADH binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	216	SGD:S000005982
Homo sapiens	217	Xenbase:XB-GENE-490836	HUMAN15493
Saccharomyces cerevisiae S288C	219	SGD:S000005982
Saccharomyces cerevisiae S288C	220	SGD:S000005982
Saccharomyces cerevisiae S288C	8854	SGD:S000005982
Saccharomyces cerevisiae S288C	11668	SGD:S000005982
Xenopus tropicalis	11669	Xenbase:XB-GENE-490836
Saccharomyces cerevisiae S288C	24188	SGD:S000005982
Saccharomyces cerevisiae S288C	26358	SGD:S000005982
Xenopus tropicalis	29539	Xenbase:XB-GENE-490836