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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Summary

Gene Symbol

Pfkfb3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

117276

PubChem

117276

Alliance of Genome Resources

RGD:619776

Annotation

Keyword

ATP-binding
Alternative splicing
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Reference proteome

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A6JLS5
A6JLS4
A6JLS8
A6JLS7
A6JLT0
O35552	6PF-2-K/Fru-2,6-P2ase brain-type isozyme RB2K
A6JLS9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of glycolytic process	TAS	9202288
fructose metabolic process	IEA
carbohydrate phosphorylation	IEA
fructose 2,6-bisphosphate metabolic process	IBA IDA IEA	17553851

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
fructose-2,6-bisphosphate 2-phosphatase activity	IBA IEA ISS TAS	9202288
ATP binding	IEA
6-phosphofructo-2-kinase activity	IBA IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **31 - 40** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5209	HGNC:8874	HUMAN00185
Canis lupus familiaris	487139		CANLF06580
Ursus americanus	123802288		URSAM26307
Ailuropoda melanoleuca	100464074		AILME11657
Mustela putorius furo	101684713		MUSPF11188
Felis catus	101100062		FELCA15834
Panthera leo	122223834		PANLE17547
Tursiops truncatus	101325875		TURTR01014
Balaenoptera musculus	118889609		BALMU28974
Loxodonta africana	100657823		LOXAF13995