GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Antiport
CBS domain
Chloride
Disease variant
Endosome
Glycoprotein
Ion transport
Neurodegeneration
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51797	Chloride channel protein 6 Chloride transport protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell volume homeostasis	NAS	8543009 9224655
chloride transmembrane transport	IEA
ion transmembrane transport	TAS
response to mechanical stimulus	IEA
monoatomic ion transmembrane transport	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction

transmembrane transport [inference]

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	NAS	8543009 9224655
intracellular membrane-bounded organelle	IBA
late endosome membrane	IEA
endosome membrane	TAS
lysosomal membrane	HDA	17897319

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
voltage-gated chloride channel activity	IDA NAS	20466723 8543009 9224655
chloride transmembrane transporter activity	IBA
ATP binding	IEA
antiporter activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

chloride transmembrane transporter activity

chloride channel activity [inference]

voltage-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride channel activity [inference]

voltage-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity

chloride channel activity [inference]

voltage-gated chloride channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

chloride channel

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
chloride transmembrane transport
chloride transport
monoatomic ion transport
voltage-gated chloride channel activity

Displaying **all 4** entries
InterPro
CBS domain superfamily
CBS domain
Chloride channel, core
Chloride channel, voltage gated

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110731	neuronal ceroid lipofuscinosis 3	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	26372		MGI:1347049	MOUSE39596
Rattus norvegicus	295586		RGD:1305379	RATNO33460
Pan troglodytes	457955	9598_0:0005aa		PANTR19951
Canis lupus familiaris	478229			CANLF07168
Bos taurus	520210			BOVIN08270
Danio rerio	568122		ZFIN:ZDB-GENE-030131-2056	DANRE41948
Macaca mulatta	714793			MACMU22652
Oryctolagus cuniculus	100008750			RABIT15282
Monodelphis domestica	100013630			MONDO23133
Ornithorhynchus anatinus	100086113			ORNAN21754

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Annotation

OrthoDB (Group)

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Acknowledgements