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ATPase, H+/K+ exchanging, gastric, alpha polypeptide

Summary

Gene Symbol

Atp4a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11944

PubChem

11944

Alliance of Genome Resources

MGI:88113

Annotation

Keyword

ATP-binding
Cell membrane
Direct protein sequencing
Hydrogen ion transport
Magnesium
Metal-binding
Phosphoprotein
Potassium transport
Proteomics identification
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q91WH7
Q64436	Gastric H(+)/K(+) ATPase subunit alpha Proton pump

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
potassium ion import across plasma membrane	IBA
intracellular sodium ion homeostasis	IBA
response to xenobiotic stimulus	IDA IMP	1324928 7762614
pH reduction	IDA	7762614
intracellular potassium ion homeostasis	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH [inference]

pH reduction

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological regulation [inference]

regulation of pH [inference]

pH reduction

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IEA ISO
plasma membrane	IBA IDA	7762614
potassium:proton exchanging ATPase complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

potassium:proton exchanging ATPase complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

potassium:proton exchanging ATPase complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

potassium:proton exchanging ATPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
P-type potassium:proton transporter activity	IBA IDA	7762614
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

alkali metal ion binding [inference]

potassium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type sodium transporter activity [inference]

P-type sodium:potassium-exchanging transporter activity

P-type potassium transmembrane transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

P-type ATPase

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
P-type sodium
intracellular sodium ion homeostasis
magnesium ion binding
metal ion binding
monoatomic ion transport
nucleotide binding

Displaying entries **1 - 10** of 12 in total

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InterPro
Cation-transporting P-type ATPase, C-terminal
Cation-transporting P-type ATPase, N-terminal
Gastric H+/K+-transporter P-type ATPase, N-terminal
HAD superfamily
HAD-like superfamily
P-type ATPase subfamily IIC, subunit alpha
P-type ATPase, A domain superfamily
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060178	familial hemiplegic migraine	Alliance of Genome Resources
DOID:0111558	Charcot-Marie-Tooth disease type 2DD	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:863	nervous system disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	495		HGNC:819	HUMAN42749
Rattus norvegicus	24216	10116_1:0003da	RGD:2177	RATNO19861
Drosophila melanogaster	48971		FB:FBgn0002921
Caenorhabditis elegans	179189		WB:WBGene00015660
Caenorhabditis elegans	182114		WB:WBGene00015338
Sus scrofa	397552			PIGXX27641
Canis lupus familiaris	431686			CANLF01199
Bos taurus	521163			BOVIN10890
Pan troglodytes	747915			PANTR17998
Oryctolagus cuniculus	100009279			RABIT16072

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements