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relaxin family peptide receptor 2

Summary

Gene Symbol

RXFP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

122042

PubChem

122042

Alliance of Genome Resources

HGNC:17318

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Leucine-rich repeat
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WXD0	G-protein coupled receptor 106 G-protein coupled receptor affecting testicular descent Leucine-rich repeat-containing G-protein coupled receptor 8 Relaxin family peptide receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
hormone-mediated signaling pathway	IBA
male gonad development	IEA
negative regulation of cell population proliferation	IEA
positive regulation of cAMP-mediated signaling	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

hormone-mediated signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular process involved in reproduction in multicellular organism [inference]

oocyte maturation

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte maturation

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

oocyte maturation

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell maturation [inference]

oocyte maturation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

hormone-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
peptide hormone binding	IEA
G protein-coupled peptide receptor activity	IBA
protein-hormone receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity

protein-hormone receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Relaxin receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled peptide receptor activity
hormone-mediated signaling pathway

Displaying **all 5** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11383	cryptorchidism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43098		FB:FBgn0039354
Mus musculus	140498		MGI:2153463	MOUSE44611
Rattus norvegicus	363866		RGD:1309449	RATNO05628
Canis lupus familiaris	450220			CANLF09821
Pan troglodytes	467256	9598_0:0039de		PANTR07547
Danio rerio	566888		ZFIN:ZDB-GENE-110408-27	DANRE08310
Macaca mulatta	721969			MACMU16761
Danio rerio	792884		ZFIN:ZDB-GENE-040426-1225	DANRE45726
Drosophila melanogaster	5740505		FB:FBgn0085440
Equus caballus	100033993			HORSE12539