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BUB1, mitotic checkpoint serine/threonine kinase

Summary

Gene Symbol

Bub1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12235

PubChem

12235

Alliance of Genome Resources

MGI:1100510

Annotation

Keyword

ATP-binding
Apoptosis
Centromere
Chromosome
Chromosome partition
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8I4YXJ8
A2APR8
O08901	BUB1A
Q8K1K8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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2

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GO Term	Evidence Code	PMID
protein phosphorylation	IEA
mitotic spindle assembly checkpoint signaling	IBA ISO ISS
cell division	IEA
regulation of sister chromatid cohesion	ISO ISS
chromatin remodeling	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

cell cycle process [inference]

chromosome segregation

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

intrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of maintenance of mitotic sister chromatid cohesion, centromeric [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of centromeric sister chromatid cohesion [inference]

regulation of maintenance of mitotic sister chromatid cohesion, centromeric [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of sister chromatid segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion

regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of maintenance of mitotic sister chromatid cohesion, centromeric [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of centromeric sister chromatid cohesion [inference]

regulation of maintenance of mitotic sister chromatid cohesion, centromeric [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome segregation

regulation of sister chromatid segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion [inference]

positive regulation of maintenance of sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion [inference]

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IBA IEA
intracellular membrane-bounded organelle	ISO
condensed chromosome, centromeric region	IDA	18084284 19965387
kinetochore	IBA IDA ISO	15226446 17227893 17938250
nucleoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

outer kinetochore

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

kinetochore

chromosomal region [inference]

chromosome, centromeric region

condensed chromosome, centromeric region

supramolecular complex [inference]

kinetochore

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
protein serine/threonine kinase activity	ISO
protein serine kinase activity	IEA
protein kinase activity	IBA ISO ISS
histone H2AS1 kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity

histone H2AS1 kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

mitotic checkpoint serine/threonine-protein kinase BUB1

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
meiotic sister chromatid cohesion, centromeric
nucleotide binding
phosphorylation

Displaying **all 5** entries
InterPro
Mad3/Bub1 homology region 1
Mitotic spindle checkpoint protein Bub1/Mad3
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070296	primary autosomal recessive microcephaly	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	699		HGNC:1148	HUMAN64308
Drosophila melanogaster	33758		FB:FBgn0031696
Drosophila melanogaster	35522		FB:FBgn0263855
Caenorhabditis elegans	172468		WB:WBGene00000275
Rattus norvegicus	296137	10116_1:001701	RGD:1311707	RATNO28174
Pan troglodytes	459484			PANTR28444
Bos taurus	514777			BOVIN01927
Macaca mulatta	696598			MACMU08299
Xenopus tropicalis	780291		Xenbase:XB-GENE-974762
Saccharomyces cerevisiae S288C	853100		SGD:S000003420

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements