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phospholipase D family member 4

Summary

Gene Symbol

PLD4

Organism

Homo sapiens (human)

External Links

NCBI Gene

122618

HGNC

23792

KEGG Gene ID

hsa:122618

PubChem

122618

Alliance of Genome Resources

HGNC:23792

Annotation

Keyword

3D-structure
Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Exonuclease
Glycoprotein
Golgi apparatus
Inflammatory response
Innate immunity
Nucleus
Proteomics identification
Reference proteome
Repeat
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
F5H2B5
Q96BZ4	Choline phosphatase 4 Phosphatidylcholine-hydrolyzing phospholipase D4 Phospholipase D family member 4 Phospholipase D4
B4DJQ6
B4DI07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IBA
establishment of localization in cell	IEA
phagocytosis	IBA ISS
inflammatory response	IEA
innate immune response	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA ISS
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	ISS TAS
phagocytic vesicle	IBA ISS
trans-Golgi network membrane	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

endocytic vesicle [inference]

phagocytic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipase D activity	ISS
single-stranded DNA 5'-3' DNA exonuclease activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

lipase activity [inference]

phospholipase activity [inference]

phospholipase D activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase D activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000166428

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16860

Name

phospholipase D3/4 [EC:3.1.4.4]

References

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0050439	Usher syndrome	DisGeNET
DOID:0110827	Usher syndrome type 2	DisGeNET
DOID:0110828	Usher syndrome type 3	DisGeNET
DOID:0110829	retinitis pigmentosa-deafness syndrome	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:2237	hepatitis	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:418	systemic scleroderma	DisGeNET
DOID:419	scleroderma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003138
Gene Name: phospholipase D family, member 4

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179105	WB:WBGene00017316
Drosophila melanogaster	35384	FB:FBgn0032923
Drosophila melanogaster	35387	FB:FBgn0263050
Latimeria chalumnae	102345980		LATCH20005
Electrophorus electricus	113571351		ELEEL09622
Esox lucius	105015650		ESOLU44372
Salmo salar	106610861		SALSA42227
Salmo trutta	115162388		SALTR58067
Salmo trutta	115172671		SALTR71844
Gadus morhua	115543820		GADMO49530

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements