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calcium channel, voltage-dependent, N type, alpha 1B subunit

Summary

Gene Symbol

Cacna1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12287

PubChem

12287

Alliance of Genome Resources

MGI:88296

Annotation

Keyword

ATP-binding
Alternative splicing
Calcium channel
Disulfide bond
Glycoprotein
Metal-binding
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O55017	Brain calcium channel III Calcium channel, L type, alpha-1 polypeptide isoform 5 Voltage-gated calcium channel subunit alpha Cav2.2
A2AIR9
A2AIS0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
positive regulation of neurotransmitter secretion	ISO
calcium ion transport	ISO
calcium ion transport	IMP	11296258 12827191
chemical synaptic transmission	IBA
neurotransmitter secretion	IMP	12827191

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

multicellular organismal response to stress [inference]

response to pain

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress [inference]

response to pain

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to organic cyclic compound [inference]

response to testosterone

response to lipid [inference]

response to testosterone

response to ketone [inference]

response to testosterone

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

response to ketone [inference]

response to testosterone

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

regulation of biological quality [inference]

regulation of blood pressure

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
voltage-gated calcium channel complex	IDA	10328888
voltage-gated calcium channel complex	IBA
membrane	IDA	18054859
dendrite	IDA	15451373
protein-containing complex	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

cellular anatomical entity [inference]

membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

dendritic shaft

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynaptic active zone

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	ISO
voltage-gated calcium channel activity	IMP	11296258 12074836 12827191
calcium ion binding	IEA
protein binding	IPI	10328888 18054859 23648579
ATP binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent calcium channel

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
high voltage-gated calcium channel activity
metal ion binding
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Ion transport domain
Voltage-dependent channel domain superfamily

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	773	SGD:S000003449
Danio rerio	774	ZFIN:ZDB-GENE-090514-4
Saccharomyces cerevisiae S288C	775	SGD:S000003449
Saccharomyces cerevisiae S288C	776	SGD:S000003449
Saccharomyces cerevisiae S288C	777	SGD:S000003449
Saccharomyces cerevisiae S288C	778	SGD:S000003449
Saccharomyces cerevisiae S288C	779	SGD:S000003449
Saccharomyces cerevisiae S288C	6323	SGD:S000003449
Saccharomyces cerevisiae S288C	6326	SGD:S000003449
Saccharomyces cerevisiae S288C	6328	SGD:S000003449

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