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delta 4-desaturase, sphingolipid 2

Summary

Gene Symbol

DEGS2

Aliases

DES2
FADS8
dihydroceramide desaturase 2
sphingolipid delta(4)-desaturase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

123099

HGNC

20113

KEGG Gene ID

hsa:123099

PubChem

123099

Alliance of Genome Resources

HGNC:20113

Annotation

Keyword

Endoplasmic reticulum
Lipid biosynthesis
Myristate
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6QHC5	Degenerative spermatocyte homolog 2 Sphingolipid 4-desaturase Sphingolipid C4-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ceramide biosynthetic process	IBA
sphinganine metabolic process	IBA
sphingolipid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphinganine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphinganine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

sphingoid metabolic process [inference]

sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sphingolipid C4-monooxygenase activity	IEA
sphingosine hydroxylase activity
sphingolipid delta-4 desaturase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

sphingosine hydroxylase activity

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

sphingolipid C4-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

sphingolipid C4-monooxygenase activity

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [inference]

sphingolipid delta-4 desaturase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K04712

Name

sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]

References

11937514

Rhea

H⁺ + O₂ + an N-acylsphinganine

H₂O + an N-acyl-(4R)-4-hydroxysphinganine

Enzyme

1.14.18.5

PMID

H⁺ + O₂ + an N-acylsphinganine

H₂O + an N-acylsphing-4-enine

Enzyme

1.14.19.17

PMID

a dihydroceramide + H⁺ + O₂

a phytoceramide + H₂O

Enzyme

1.14.18.5

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:150	disease of mental health	DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:2468	psychotic disorder	DisGeNET
DOID:526	human immunodeficiency virus infectious disease	DisGeNET
DOID:5419	schizophrenia	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:635	acquired immunodeficiency syndrome	DisGeNET
DOID:9256	colorectal cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006635
Gene Name: delta(4)-desaturase, sphingolipid 2

Ortholog

Displaying entries **21 - 30** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pseudonaja textilis	113434998		PSETE06158
Meleagris gallopavo	100547168		MELGA11111
Serinus canaria	103826431		SERCA04163
Sarcophilus harrisii	100933090		SARHA14309
Callithrix jacchus	100409287		CALJA02780
Cercocebus atys	105596688		CERAT09059
Macaca fascicularis	102146231		MACFA40000
Macaca mulatta	717222		MACMU42532
Macaca nemestrina	105467423		MACNE10717
Gorilla gorilla gorilla	101143812		GORGO08602

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Last updated: August 19, 2024