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AGBL carboxypeptidase 1

Summary

Gene Symbol

AGBL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

123624

PubChem

123624

Alliance of Genome Resources

HGNC:26504

Annotation

Keyword

Carboxypeptidase
Corneal dystrophy
Cytoplasm
Metal-binding
Metalloprotease
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96MI9	ATP/GTP-binding protein-like 1 Protein deglutamylase CCP4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
protein side chain deglutamylation	ISS
C-terminal protein deglutamylation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
microtubule cytoskeleton	IBA
cytosol	IEA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

Displaying **all 3** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
tubulin binding	IBA ISS
metallocarboxypeptidase activity	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxypeptidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
metallocarboxypeptidase activity
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Cytosolic carboxypeptidase, N-terminal
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11555	Fuchs' endothelial dystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 49 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100387973			CALJA37396
Pongo abelii	100457638	9601_0:003b43		PONAB09159
Xenopus tropicalis	100485158		Xenbase:XB-GENE-950762
Xenopus tropicalis	100489375		Xenbase:XB-GENE-5759092
Danio rerio	100536841			DANRE27669
Nomascus leucogenys	100584395			NOMLE31853
Cavia porcellus	100733157			CAVPO06897
Pan paniscus	100992666	9597_0:003ee4		PANPA14057
Papio anubis	101011902			PAPAN37601
Felis catus	101092766			FELCA14911

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024