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catenin alpha 2

Summary

Gene Symbol

Ctnna2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12386

PubChem

12386

Alliance of Genome Resources

MGI:88275

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cytoskeleton
Developmental protein
Differentiation
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61301	Alpha N-catenin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of Arp2/3 complex-mediated actin nucleation	ISO ISS
modification of postsynaptic actin cytoskeleton	IDA IMP	15034585
cell-cell adhesion	IBA ISS
regulation of neuron projection development	ISO ISS
brain morphogenesis	IMP	12089526 16691566

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell motility [inference]

cell migration

cell migration in hindbrain [inference]

hindbrain radial glia guided cell migration [inference]

radial glia guided migration of Purkinje cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure [inference]

modification of postsynaptic actin cytoskeleton

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of synapse organization [inference]

regulation of synapse structural plasticity

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
adherens junction	IBA IDA	12695331 15630473 16457793 19129494
postsynaptic density, intracellular component	IDA	8909549
extrinsic component of postsynaptic membrane	IDA	8909549
actin cytoskeleton	IEA
lamellipodium	IDA	14657280

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
actin filament binding	IBA ISO ISS
beta-catenin binding	IBA
identical protein binding	IPI	23417122
structural molecule activity	IEA
cadherin binding	IEA

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding [inference]

beta-catenin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

catenin alpha-2

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin filament binding
beta-catenin binding
cadherin binding
cell differentiation
cell migration
structural molecule activity

Displaying **all 3** entries
InterPro
Alpha-catenin/vinculin-like superfamily
Alpha-catenin
Vinculin/alpha-catenin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090131	complex cortical dysplasia with other brain malformations	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 78 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pseudonaja textilis	113448299		PSETE21927
Athene cunicularia	113479032		ATHCN08228
Bos indicus x Bos taurus	113901332		BOBOX20249
Marmota flaviventris	114099460	93162_0:002594
Grammomys surdaster	114616834	491861_0:0007ea
Peromyscus leucopus	114694443	10041_0:00104b
Mastomys coucha	116099100	35658_0:001fa1
Corvus moneduloides	116443673		CORMO21494
Rattus rattus	116903665	10117_0:0029a0
Rhinolophus ferrumequinum	117033171		RHIFE24832