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catenin alpha 2

Summary

Gene Symbol

Ctnna2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12386

PubChem

12386

Alliance of Genome Resources

MGI:88275

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cytoskeleton
Developmental protein
Differentiation
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61301	Alpha N-catenin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of Arp2/3 complex-mediated actin nucleation	ISO ISS
modification of postsynaptic actin cytoskeleton	IDA IMP	15034585
cell-cell adhesion	IBA ISS
regulation of neuron projection development	ISO ISS
brain morphogenesis	IMP	12089526 16691566

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell motility [inference]

cell migration

cell migration in hindbrain [inference]

hindbrain radial glia guided cell migration [inference]

radial glia guided migration of Purkinje cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure [inference]

modification of postsynaptic actin cytoskeleton

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of synapse organization [inference]

regulation of synapse structural plasticity

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
catenin complex	IBA
axon	IMP	16691566
basolateral plasma membrane	IDA	9950951
nucleus	IEA
cytoplasm	ISO ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
actin filament binding	IBA ISO ISS
beta-catenin binding	IBA
identical protein binding	IPI	23417122
structural molecule activity	IEA
cadherin binding	IEA

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding [inference]

beta-catenin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

catenin alpha-2

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin filament binding
beta-catenin binding
cadherin binding
cell differentiation
cell migration
structural molecule activity

Displaying **all 3** entries
InterPro
Alpha-catenin/vinculin-like superfamily
Alpha-catenin
Vinculin/alpha-catenin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090131	complex cortical dysplasia with other brain malformations	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 78 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cercocebus atys	105597607		CERAT37782
Aotus nancymaae	105717120		AOTNA15870
Propithecus coquereli	105813690		PROCO26669
Dipodomys ordii	105997398	10020_0:003dfb	DIPOR18188
Marmota marmota marmota	107154248	9994_0:00382c
Rhinopithecus bieti	108539664		RHIBE27884
Castor canadensis	109678026	51338_0:004f57
Mus caroli	110295850	10089_0:0018fd
Mus pahari	110316267	10093_0:00084a
Urocitellus parryii	113187950	9999_0:001f1c