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CD2-associated protein

Summary

Gene Symbol

Cd2ap

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12488

PubChem

12488

Alliance of Genome Resources

MGI:1330281

Annotation

Keyword

3D-structure
Cell junction
Cell projection
Coiled coil
Cytoskeleton
Isopeptide bond
Mitosis
Phosphoprotein
Reference proteome
Repeat
SH3 domain
SH3-binding
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JLQ0	Mesenchyme-to-epithelium transition protein with SH3 domains 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 76 in total

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GO Term	Evidence Code	PMID
immunological synapse formation	IMP	14512504
kidney development	IDA	15213232
kidney development	IMP	15213232 30612599
liver development	IDA	29729186
endothelium development	IMP	25968128

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein phosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein phosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion mediated by cadherin

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

neurotrophin signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cell recognition [inference]

cell-cell recognition [inference]

immunological synapse formation

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation

cell growth [inference]

developmental cell growth [inference]

collateral sprouting

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

cell motility [inference]

cell migration

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

localization of cell

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

protein complex oligomerization [inference]

protein heterooligomerization

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction organization [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

protein complex oligomerization [inference]

protein heterooligomerization

membrane organization

supramolecular fiber organization [inference]

actin filament organization

actin polymerization or depolymerization [inference]

actin filament polymerization

export from cell [inference]

secretion by cell [inference]

protein secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

cytokine production [inference]

transforming growth factor beta production [inference]

transforming growth factor beta1 production

system process [inference]

renal system process [inference]

renal absorption [inference]

renal protein absorption [inference]

renal albumin absorption

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

endothelium development

connective tissue development [inference]

adipose tissue development

glomerulus development

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

hematopoietic or lymphoid organ development [inference]

lymph node development

gland development [inference]

liver development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

collateral sprouting

developmental growth [inference]

developmental cell growth [inference]

collateral sprouting

developmental growth involved in morphogenesis [inference]

collateral sprouting

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to growth factor [inference]

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

protein transport

protein secretion

nitrogen compound transport [inference]

protein transport

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

localization of cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

neurotrophin TRK receptor signaling pathway

neurotrophin signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of molecular function [inference]

regulation of binding [inference]

regulation of protein binding

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
fibrillar center	ISO
fibrillar center	IEA
ruffle	ISO
ruffle	IEA
podosome	IDA	17606992

GO Hierarchy

cellular component

protein-containing complex

filamentous actin

cellular anatomical entity [inference]

fibrillar center

cytoplasm

cell cortex

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

trans-Golgi network membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

anchoring junction [inference]

cell-cell junction

filtration diaphragm [inference]

slit diaphragm

site of polarized growth [inference]

growth cone

cell leading edge

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

podosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

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GO Term	Evidence Code	PMID
actin binding	IDA	15956777 17606992 26546360
vascular endothelial growth factor receptor binding	ISO
protein binding	IPI	10913159 11733379 12559036 17606992 18753381 19679673 22809625 26546360 27076424 27474268
beta-catenin binding	ISO
SH3 domain binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

vascular endothelial growth factor receptor binding

growth factor receptor binding [inference]

vascular endothelial growth factor receptor binding

beta-catenin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

protein domain specific binding [inference]

SH3 domain binding

phosphatidylinositol 3-kinase binding [inference]

phosphatidylinositol 3-kinase regulatory subunit binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112245	focal segmental glomerulosclerosis 3	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	12488	Xenbase:XB-GENE-987810
Homo sapiens	23607	Xenbase:XB-GENE-987810	HUMAN85114
Drosophila melanogaster	30011	FB:FBgn0027598
Rattus norvegicus	316258		RATNO42705
Pan troglodytes	472241		PANTR38328
Canis lupus familiaris	474928		CANLF02823
Danio rerio	494040		DANRE19812
Bos taurus	533188		BOVIN18615
Macaca mulatta	705221		MACMU33701
Monodelphis domestica	100014892		MONDO14889

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements