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calreticulin 3

Summary

Gene Symbol

CALR3

Aliases

CRT2
CT93
FLJ25355
MGC26577
calsperin
cancer/testis antigen 93

Organism

Homo sapiens (human)

External Links

NCBI Gene

125972

HGNC

20407

KEGG Gene ID

hsa:125972

PubChem

125972

Alliance of Genome Resources

HGNC:20407

Annotation

Keyword

Cardiomyopathy
Chaperone
Coiled coil
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lectin
Metal-binding
Reference proteome
Repeat
Signal
Spermatogenesis
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96L12	Calreticulin-2 Calsperin
A0A140VJF7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
biological_process	ND
ERAD pathway	IBA
spermatogenesis	IEA
protein folding	IBA
cell differentiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

protein folding

cellular developmental process [inference]

cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nuclear envelope	IDA	21590275
endoplasmic reticulum lumen	IDA	21590275
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein folding chaperone	IEA
calcium ion binding	IDA	21590275
carbohydrate binding	IEA
unfolded protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

unfolded protein binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000269058

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K10098

Name

calreticulin 3

References

21590275

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET
DOID:0080326	familial hypertrophic cardiomyopathy	DisGeNET
DOID:0110307	hypertrophic cardiomyopathy 1	DisGeNET
DOID:11984	hypertrophic cardiomyopathy	DisGeNET DisGeNET
DOID:12306	vitiligo	DisGeNET
DOID:12932	endomyocardial fibrosis	DisGeNET DisGeNET
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:83	cataract	DisGeNET

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178997	WB:WBGene00000802
Drosophila melanogaster	41166	FB:FBgn0005585
Danio rerio	30248	ZFIN:ZDB-GENE-000208-17
Xenopus laevis	108714315	Xenbase:XB-GENE-17344975
Xenopus laevis	108714990	Xenbase:XB-GENE-17344976
Callithrix jacchus	100388538		CALJA23475
Cercocebus atys	105571315		CERAT21968
Macaca mulatta	719532		MACMU18710
Papio anubis	101018914		PAPAN22249
Gorilla gorilla gorilla	101138342		GORGO16910

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Last updated: August 19, 2024