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alkaline ceramidase 1

Summary

Gene Symbol

ACER1

Organism

Homo sapiens (human)

External Links

NCBI Gene

125981

HGNC

18356

KEGG Gene ID

hsa:125981

PubChem

125981

Alliance of Genome Resources

HGNC:18356

Annotation

Keyword

Calcium
Endoplasmic reticulum
Hydrolase
Metal-binding
Reference proteome
Sphingolipid metabolism
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDN7	Acylsphingosine deacylase 3 N-acylsphingosine amidohydrolase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

« First

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GO Term	Evidence Code	PMID
sebaceous gland development	IEA
sphingolipid metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

animal organ development [inference]

gland development [inference]

sebaceous gland development

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to alkaline pH

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
endoplasmic reticulum	IBA IDA	17713573

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
dihydroceramidase activity
metal ion binding	IEA
ceramidase activity
N-acylsphingosine amidohydrolase activity	IBA IDA IMP TAS	17713573 20207939 20628055

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

dihydroceramidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

dihydroceramidase activity

ceramidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ceramide biosynthetic process
ceramide catabolic process
ceramide metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
hydrolase activity
phytoceramidase activity
sphingolipid metabolic process

Displaying 1 entry
InterPro
Alkaline ceramidase

KEGG BRITE Database

Orthology

K01441

Name

alkaline ceramidase [EC:3.5.1.23]

References

12783875

Rhea

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000475
Gene Name: alkaline ceramidase 1

Ortholog

Displaying entries **1 - 10** of 77 in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	171168		MGI:2181962	MOUSE20309
Caenorhabditis elegans	189124		WB:WBGene00020947
Drosophila melanogaster	250736		FB:FBgn0045064
Rattus norvegicus	301118		RGD:1588582	RATNO43733
Pan troglodytes	468681	9598_0:004ea1		PANTR16907
Bos taurus	518021			BOVIN32813
Danio rerio	550266		ZFIN:ZDB-GENE-050417-70	DANRE43443
Canis lupus familiaris	611739			CANLF07971
Macaca mulatta	699093			MACMU20752
Monodelphis domestica	100025621			MONDO19859

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Last updated: December 9, 2024