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cadherin, EGF LAG seven-pass G-type receptor 1

Summary

Gene Symbol

Celsr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12614

PubChem

12614

Alliance of Genome Resources

MGI:1100883

Annotation

Keyword

Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35161

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **21 - 21** of 21 in total

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GO Term	Evidence Code	PMID
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP	20223754

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

behavior [inference]

locomotory behavior

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

establishment of planar polarity of embryonic epithelium

establishment of body hair or bristle planar orientation [inference]

establishment of body hair planar orientation

embryonic morphogenesis [inference]

inner ear morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in lung branching [inference]

lateral sprouting from an epithelium [inference]

lateral sprouting involved in lung morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

hair follicle development

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity [inference]

regulation of establishment of planar polarity involved in neural tube closure [inference]

planar cell polarity pathway involved in neural tube closure

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IDA	20353824
plasma membrane	IEA ISO
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18849982 23292348
calcium ion binding	TAS	12842012
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cadherin EGF LAG seven-pass G-type receptor 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
neurogenesis

Displaying 1 entry
InterPro
Cadherin-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9620		HGNC:1850	HUMAN61100
Drosophila melanogaster	36125		FB:FBgn0024836
Caenorhabditis elegans	179788		WB:WBGene00001475
Rattus norvegicus	300128	10116_1:00282c	RGD:1560078	RATNO37411
Danio rerio	368436		ZFIN:ZDB-GENE-030616-78	DANRE34235
Pan troglodytes	458920			PANTR26843
Canis lupus familiaris	481203			CANLF01490
Bos taurus	522422			BOVIN30892
Danio rerio	556520		ZFIN:ZDB-GENE-050823-4
Macaca mulatta	718440			MACMU02475

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024