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cadherin, EGF LAG seven-pass G-type receptor 1

Summary

Gene Symbol

Celsr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12614

PubChem

12614

Alliance of Genome Resources

MGI:1100883

Annotation

Keyword

Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35161

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
anterior/posterior pattern specification	IMP	18849982 19357712
cell-cell adhesion	IBA
wound healing	IGI	20643356
motor neuron migration	IMP	20631168
inner ear morphogenesis	IMP	12842012

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

behavior [inference]

locomotory behavior

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

establishment of planar polarity of embryonic epithelium

establishment of body hair or bristle planar orientation [inference]

establishment of body hair planar orientation

embryonic morphogenesis [inference]

inner ear morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in lung branching [inference]

lateral sprouting from an epithelium [inference]

lateral sprouting involved in lung morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

hair follicle development

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity [inference]

regulation of establishment of planar polarity involved in neural tube closure [inference]

planar cell polarity pathway involved in neural tube closure

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IDA	20353824
plasma membrane	IEA ISO
nucleoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18849982 23292348
calcium ion binding	TAS	12842012
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cadherin EGF LAG seven-pass G-type receptor 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
neurogenesis

Displaying 1 entry
InterPro
Cadherin-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **107** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	100038051		Xenbase:XB-GENE-853455
Equus caballus	100053508			HORSE26012
Ornithorhynchus anatinus	100076286			ORNAN05608
Taeniopygia guttata	100221214			TAEGU08456
Callithrix jacchus	100388271			CALJA19142
Pongo abelii	100453063			PONAB22146
Nomascus leucogenys	100580016			NOMLE34577
Oreochromis niloticus	100704608			ORENI25332
Cavia porcellus	100724703	10141_0:0005a8		CAVPO23992
Otolemur garnettii	100940997			OTOGA17298

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements