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ciliary neurotrophic factor receptor

Summary

Gene Symbol

CNTFR

Organism

Homo sapiens (human)

External Links

NCBI Gene

1271

HGNC

2170

KEGG Gene ID

hsa:1271

PubChem

1271

Alliance of Genome Resources

HGNC:2170

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
GPI-anchor
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P26992

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
negative regulation of motor neuron apoptotic process	IEA
sex differentiation	IEA
motor neuron apoptotic process	IEA
suckling behavior	IEA
nervous system development		7585948

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

ciliary neurotrophic factor-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

reproductive process [inference]

developmental process involved in reproduction [inference]

sex differentiation

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

suckling behavior

developmental process [inference]

developmental process involved in reproduction [inference]

sex differentiation

anatomical structure development [inference]

brainstem development

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development

system development [inference]

nervous system development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

ciliary neurotrophic factor-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extrinsic component of membrane		1648265
external side of plasma membrane	IBA
plasma membrane
apical plasma membrane	IDA	21912637
CNTFR-CLCF1 complex	IBA IDA	11285233

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

CNTFR-CLCF1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

extrinsic component of membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine binding	IBA IPI	15272019
cytokine receptor activity	IBA
signaling receptor binding	IPI	12707266
ciliary neurotrophic factor receptor activity	IBA IDA	12643274
protein binding	IPI	18775332 19386761 20584990 26858303

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

immune receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000122756

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05059

Name

ciliary neurotrophic factor receptor

References

1648265

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0060250	idiopathic scoliosis	DisGeNET
DOID:0060294	cold-induced sweating syndrome	DisGeNET
DOID:0070323	childhood acute myeloid leukemia	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET
DOID:0080329	cold-induced sweating syndrome 1	DisGeNET
DOID:1094	attention deficit hyperactivity disorder	DisGeNET
DOID:162	cancer	DisGeNET
DOID:3070	high grade glioma	DisGeNET
DOID:3071	gliosarcoma	DisGeNET
DOID:318	progressive muscular atrophy	DisGeNET

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Latimeria chalumnae	102358771		LATCH11447
Danio rerio	368438	ZFIN:ZDB-GENE-030616-82	DANRE01286
Astyanax mexicanus	103022731		ASTMX13359
Ictalurus punctatus	108277340		ICTPU08700
Electrophorus electricus	113577622		ELEEL21112
Salmo trutta	115160200		SALTR70183
Salmo trutta	115191022		SALTR49005
Xenopus laevis	108707362	Xenbase:XB-GENE-17338587
Xenopus tropicalis	100135712	Xenbase:XB-GENE-923386
Chrysemys picta bellii	101938440		CHRPI36418

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KEGG BRITE Database

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Acknowledgements