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carboxypeptidase E

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12876

PubChem

12876

Alliance of Genome Resources

MGI:101932

Annotation

Keyword

Carboxypeptidase
Cleavage on pair of basic residues
Cytoplasmic vesicle
Direct protein sequencing
Disease variant
Glycoprotein
Membrane
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q00493	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase
Q543R4	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cardiac left ventricle morphogenesis	ISO
cardiac left ventricle morphogenesis	IEA
proteolysis
peptide metabolic process	ISO
peptide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin metabolic process [inference]

insulin processing

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

organic substance transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of branching morphogenesis of a nerve

negative regulation of multicellular organismal process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve [inference]

negative regulation of branching morphogenesis of a nerve

negative regulation of developmental process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of branching morphogenesis of a nerve

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve [inference]

negative regulation of branching morphogenesis of a nerve

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

hormone metabolic process [inference]

peptide hormone processing [inference]

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	ISO
extracellular space	IBA
extracellular space	HDA	24006456
Golgi apparatus	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

plasma membrane region [inference]

synaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

dense core granule

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity	ISO
carboxypeptidase activity	IMP	7663508
metallocarboxypeptidase activity	IMP	9348219
metallocarboxypeptidase activity	IBA
protein binding	IPI	16219686

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

neurexin family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

carboxypeptidase E

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
V: Defense mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallocarboxypeptidase activity
metallopeptidase activity
peptide metabolic process
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Carboxypeptidase-like, regulatory domain superfamily
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1363	Xenbase:XB-GENE-952270	HUMAN78030
Caenorhabditis elegans	1368	WB:WBGene00012073
Caenorhabditis elegans	1369	WB:WBGene00012073
Caenorhabditis elegans	8532	WB:WBGene00001189
Caenorhabditis elegans	11568	WB:WBGene00001189
Xenopus tropicalis	12876	Xenbase:XB-GENE-952270
Rattus norvegicus	25669	Xenbase:XB-GENE-952270	RATNO11191
Xenopus tropicalis	30998	Xenbase:XB-GENE-952270
Caenorhabditis elegans	55987	WB:WBGene00001189
Caenorhabditis elegans	56264	WB:WBGene00001189