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charged multivesicular body protein 4B

Summary

Gene Symbol

CHMP4B

Organism

Homo sapiens (human)

External Links

NCBI Gene

128866

PubChem

128866

Alliance of Genome Resources

HGNC:16171

Annotation

Keyword

3D-structure
Acetylation
Cataract
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Endosome
Host-virus interaction
Membrane
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H444	Chromatin-modifying protein 4b SNF7 homolog associated with Alix 1 SNF7-2 Vacuolar protein sorting-associated protein 32-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 38 in total

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GO Term	Evidence Code	PMID
viral budding via host ESCRT complex	IGI	24107264
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA	17984323
viral budding	IMP	17701905
viral budding from plasma membrane	IDA	24878737
viral budding from plasma membrane	IMP	14505570

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

catabolic process [inference]

cellular catabolic process [inference]

autophagy

macroautophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

macroautophagy

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

multivesicular body sorting pathway

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

cytokinetic process [inference]

mitotic cytokinetic process [inference]

midbody abscission

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

exit from mitosis

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

exit from mitosis

mitotic cytokinetic process [inference]

midbody abscission

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

macroautophagy

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

process utilizing autophagic mechanism [inference]

autophagy

macroautophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization

vacuole organization [inference]

vacuole fusion [inference]

vesicle fusion with vacuole

vesicle organization [inference]

vesicle budding from membrane

vesicle fusion [inference]

endosome organization [inference]

multivesicular body organization [inference]

multivesicular body assembly

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vacuole fusion [inference]

vesicle fusion with vacuole

organelle assembly [inference]

multivesicular body assembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

organelle assembly [inference]

multivesicular body assembly

membrane assembly [inference]

nuclear membrane reassembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex assembly [inference]

protein polymerization

membrane organization [inference]

vesicle budding from membrane

plasma membrane organization [inference]

plasma membrane repair

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

midbody abscission

membrane assembly [inference]

nuclear membrane reassembly

nuclear membrane organization [inference]

nuclear membrane reassembly

membrane fission

lysosomal membrane organization [inference]

multivesicular body-lysosome fusion

viral process [inference]

viral release from host cell [inference]

non-lytic viral release [inference]

viral budding from plasma membrane

viral budding

multicellular organismal process [inference]

system process [inference]

nervous system process

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

exit from host cell [inference]

viral release from host cell [inference]

non-lytic viral release [inference]

viral budding from plasma membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

multivesicular body sorting pathway

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

Displaying entries **16 - 20** of 24 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	24878737
cytoplasmic side of plasma membrane	IDA	18209100
cytoplasmic side of plasma membrane	IBA
membrane coat	IDA	24878737
midbody	IDA	21310966 22724069 26040712

GO Hierarchy

cellular component

protein-containing complex [inference]

ESCRT complex [inference]

ESCRT III complex

membrane protein complex [inference]

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

amphisome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

midbody

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome [inference]

multivesicular body

intracellular non-membrane-bounded organelle [inference]

kinetochore

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule [inference]

kinetochore microtubule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12860994 14505570 14519844 16189514 16730941 16856878 17174262 17500595 17711858 18434552 18511562 18641129 19523902 20208530 21543490 21889351 21975012 22162750 22484091 23051622 26496610 32296183 32814053 33349255 34818527 35271311
identical protein binding	IPI	16730941 18209100 19523902
protein homodimerization activity	IPI	14519844
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Charged multivesicular body protein

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
late endosome to vacuole transport via multivesicular body sorting pathway
vacuolar transport

Displaying 1 entry
InterPro
Snf7 family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110265	cataract 31 multiple types	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **106** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	75608		MOUSE32161
Xenopus tropicalis	128866	Xenbase:XB-GENE-941865
Danio rerio	393164		DANRE39141
Danio rerio	406766		DANRE43025
Canis lupus familiaris	485842		CANLF09466
Bos taurus	616164		BOVIN05122
Rattus norvegicus	679886		RATNO30245
Macaca mulatta	709004		MACMU02040
Pan troglodytes	747134		PANTR24671
Monodelphis domestica	100032325		MONDO06474

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements