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cartilage oligomeric matrix protein

Summary

Gene Symbol

COMP

Organism

Homo sapiens (human)

External Links

NCBI Gene

1311

PubChem

1311

Alliance of Genome Resources

HGNC:2227

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Calcium
Cell adhesion
Direct protein sequencing
Disease variant
Disulfide bond
Dwarfism
EGF-like domain
Extracellular matrix
Glycoprotein
Heparin-binding
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P49747	Thrombospondin-5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	7670472
chondrocyte development	IEA
growth plate cartilage development	IEA
apoptotic process	IEA
response to unfolded protein	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular metabolic process [inference]

cellular senescence

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

chondrocyte proliferation

cellular metabolic process [inference]

cellular senescence

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

export from cell [inference]

secretion by cell [inference]

protein secretion

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

nervous system process [inference]

neuromuscular process [inference]

musculoskeletal movement

multicellular organism growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

multicellular organismal movement [inference]

musculoskeletal movement

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

animal organ development [inference]

skin development

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis [inference]

growth plate cartilage development

system development [inference]

skeletal system development

appendage development [inference]

limb development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development [inference]

vascular associated smooth muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

organic substance transport [inference]

protein transport [inference]

protein secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of hemostasis

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA	32747625
extracellular region	HDA	27068509
extracellular space	HDA	20551380
extracellular matrix	IDA	18285447

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protease binding	IPI	18485748
integrin binding	IEA
extracellular matrix structural constituent	RCA	20551380
calcium ion binding	IDA	10852928 11084047
protein binding	IPI	12225811 15075323 16051604 16611630 17588949 18485748 25416956 31515488 32296183

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

cytokine binding [inference]

BMP binding

proteoglycan binding

heparan sulfate proteoglycan binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 7** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like domain
TSP type-3 repeat
Thrombospondin, C-terminal
Thrombospondin, type 3 repeat
Thrombospondin, type 3-like repeat

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0070303	multiple epiphyseal dysplasia 1	Alliance of Genome Resources
DOID:0070467	carpal tunnel syndrome 2	Alliance of Genome Resources
DOID:0080047	pseudoachondroplasia	Alliance of Genome Resources
DOID:2256	osteochondrodysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1311	Xenbase:XB-GENE-994160
Drosophila melanogaster	7059	FB:FBgn0031850
Drosophila melanogaster	7060	FB:FBgn0031850
Mus musculus	12845	Xenbase:XB-GENE-994160	MOUSE60268
Drosophila melanogaster	21827	FB:FBgn0031850
Drosophila melanogaster	21828	FB:FBgn0031850
Rattus norvegicus	25304	Xenbase:XB-GENE-994160	RATNO11453
Xenopus tropicalis	33941	Xenbase:XB-GENE-994160
Drosophila melanogaster	252849	FB:FBgn0031850
Drosophila melanogaster	252850	FB:FBgn0031850

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements