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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Summary
- Gene Symbol
-
- Slc6a3
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Cell membrane
- Cell projection
- Disulfide bond
- Glycoprotein
- Metal-binding
- Neurotransmitter transport
- Reference proteome
- Sodium
- Symport
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q61327 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to cocaine | ||
| response to nicotine | ||
| cognition |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| axon terminus | ||
| flotillin complex | ||
| postsynaptic membrane | ||
| neuronal cell body membrane | ||
| neuronal cell body |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| amine binding | ||
| heterocyclic compound binding | ||
| metal ion binding | ||
| protease binding | ||
| norepinephrine:sodium symporter activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- sodium-dependent dopamine transporter
- Functional Category
-
- G: Carbohydrate transport and metabolism
- I: Lipid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
| Gene Ontology |
|---|
| dopamine uptake involved in synaptic transmission |
| dopamine uptake |
| metal ion binding |
| neurotransmitter transport |
| symporter activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0070489 | classic dopamine transporter deficiency syndrome | |
| DOID:0080832 | mild cognitive impairment | |
| DOID:0080855 | Parkinsonism | |
| DOID:0090145 | dopamine beta-hydroxylase deficiency | |
| DOID:10763 | hypertension | |
| DOID:1094 | attention deficit hyperactivity disorder | |
| DOID:11119 | Gilles de la Tourette syndrome | |
| DOID:12700 | hyperprolactinemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 131921866 | 42410_0:0036c1 | |||
| 134730363 | PANPA31459 |
