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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Summary
- Gene Symbol
-
- Slc6a3
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Cell membrane
- Cell projection
- Disulfide bond
- Glycoprotein
- Metal-binding
- Neurotransmitter transport
- Reference proteome
- Sodium
- Symport
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q61327 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to cocaine | ||
| response to nicotine | ||
| cognition |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| axon terminus | ||
| flotillin complex | ||
| postsynaptic membrane | ||
| neuronal cell body membrane | ||
| neuronal cell body |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| dopamine binding | ||
| protein binding | ||
| monoamine transmembrane transporter activity | ||
| signaling receptor binding | ||
| protein-containing complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- sodium-dependent dopamine transporter
- Functional Category
-
- G: Carbohydrate transport and metabolism
- I: Lipid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
| Gene Ontology |
|---|
| dopamine uptake involved in synaptic transmission |
| dopamine uptake |
| metal ion binding |
| neurotransmitter transport |
| symporter activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0070489 | classic dopamine transporter deficiency syndrome | |
| DOID:0080832 | mild cognitive impairment | |
| DOID:0080855 | Parkinsonism | |
| DOID:0090145 | dopamine beta-hydroxylase deficiency | |
| DOID:10763 | hypertension | |
| DOID:1094 | attention deficit hyperactivity disorder | |
| DOID:11119 | Gilles de la Tourette syndrome | |
| DOID:12700 | hyperprolactinemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 102008439 | 34839_0:003fd9 | CHILA20762 | ||
| 102142756 | MACFA35132 | |||
| 102187167 | CAPHI13326 | |||
| 102424965 | MYOLU00340 | |||
| 102927557 | 230844_0:003dfb | |||
| 103026128 | ASTMX09085 | |||
| 103214932 | CHLSB13892 | |||
| 103271220 | CARSF27614 | |||
| 103749676 | 1026970_0:003f26 | NANGA10947 | ||
| 104668699 | RHIRO35745 |
