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glycerate kinase

Summary

Gene Symbol

GLYCTK

Aliases

HBEBP2
HBEBP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

132158

HGNC

24247

KEGG Gene ID

hsa:132158

PubChem

132158

Alliance of Genome Resources

HGNC:24247

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoplasm
Disease variant
Kinase
Mitochondrion
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IVS8	HBeAg-binding protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein phosphorylation	IBA IDA	16753811
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	IDA TAS
cytoplasm	IBA IDA	16753811
Golgi apparatus	IDA
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycerate kinase activity	EXP IBA IDA	16753811 2537226 31837836
ATP binding	IEA
protein binding	IPI	16189514 19060904 25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

glycerate kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

glycerate kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168237

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K11529

Name

glycerate 2-kinase [EC:2.7.1.165]

References

Rhea

(R)-glycerate + ATP

H⁺ + ADP + (2R)-3-phosphoglycerate

Enzyme

2.7.1.31

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 18 in total

1

2

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050841	focal hand dystonia	DisGeNET
DOID:0111626	D-glyceric aciduria	Alliance of Genome Resources
DOID:1059	intellectual disability	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11832	visual epilepsy	DisGeNET
DOID:12697	locked-in syndrome	DisGeNET
DOID:12835	quadriplegia	DisGeNET
DOID:1826	epilepsy	DisGeNET
DOID:2481	obsolete infantile epileptic encephalopathy	DisGeNET
DOID:2977	primary hyperoxaluria	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 55 in total

1

2

3

4

5

6

Next ›

Last »
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000054	Micropenis
HP:0000252	Microcephaly
HP:0000253	Progressive microcephaly
HP:0000365	Hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000490	Deeply set eye
HP:0000609	Optic nerve hypoplasia
HP:0000729	Autistic behavior
HP:0000750	Delayed speech and language development

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:220120	D-glyceric aciduria
ORPHA:941	D-glyceric aciduria

PubChem Disease

MedGen Diseases

D-Glyceric aciduria

OMIM Phenotypes

D-GLYCERIC ACIDURIA

KEGG Diseases

D-glyceric aciduria

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 83 in total

1

2

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	266887	WB:WBGene00015733
Drosophila melanogaster	33431	FB:FBgn0031428
Ciona intestinalis	100183164		CIOIN09881
Callorhinchus milii	103176631		CALMI11010
Latimeria chalumnae	102347757		LATCH19662
Danio rerio	570678	ZFIN:ZDB-GENE-061013-308	DANRE38526
Astyanax mexicanus	103036018		ASTMX19366
Ictalurus punctatus	108272291		ICTPU02917
Electrophorus electricus	113568905		ELEEL50537
Salmo salar	106565974		SALSA62971

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024