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Guidelines

MIRAGE

adenosine deaminase domain containing 1

Summary

Gene Symbol

ADAD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

132612

PubChem

132612

Alliance of Genome Resources

HGNC:30713

JoGo

ADAD1

TogoVar

ADAD1

Annotation

Keyword

Alternative splicing
Developmental protein
Nucleus
Proteomics identification
RNA-binding
Reference proteome
Spermatogenesis

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VKH5	Testis nuclear RNA-binding protein
Q96M93	Testis nuclear RNA-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
adenosine to inosine editing	IBA
RNA processing	IBA
spermatid development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

RNA modification [inference]

base conversion or substitution editing [inference]

adenosine to inosine editing

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
male germ cell nucleus	IEA
nucleolus	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

male germ cell nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

male germ cell nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
double-stranded RNA binding	IBA
double-stranded RNA adenosine deaminase activity	IBA
adenosine deaminase activity	IEA
tRNA-specific adenosine deaminase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

adenosine deaminase activity

deaminase activity [inference]

adenosine deaminase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adenosine deaminase domain-containing protein 1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
adenosine deaminase activity
adenosine to inosine editing
double-stranded RNA binding
tRNA-specific adenosine deaminase activity

Displaying **all 3** entries
InterPro
ADAD1, double-stranded RNA binding domain
Adenosine deaminase/editase
Double-stranded RNA-binding domain

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026