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adrenomedullin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

133

PubChem

133

Alliance of Genome Resources

HGNC:259

Annotation

Keyword

3D-structure
Amidation
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Hormone
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35318

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 45 in total

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GO Term	Evidence Code	PMID
odontogenesis of dentin-containing tooth	IEA
animal organ regeneration	IEA
inflammatory response	TAS	8524787
neuron projection regeneration	IEA
antibacterial humoral response	IDA	10225288

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

metabolic process [inference]

hormone metabolic process [inference]

androgen metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

adrenomedullin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

cell population proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

negative regulation of vascular permeability

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

renal system process [inference]

regulation of urine volume

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

embryonic morphogenesis [inference]

branching involved in labyrinthine layer morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

spongiotrophoblast layer development

regeneration [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

growth [inference]

developmental growth

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

inflammatory response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

cellular response to stress [inference]

neuron projection regeneration

response to starvation

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to ether

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

adrenomedullin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cell population proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

regulation of vascular permeability [inference]

negative regulation of vascular permeability

regulation of body fluid levels [inference]

regulation of urine volume

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	12379507
extracellular space	IBA IDA	10225288 12379507
extracellular region	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
adrenomedullin receptor binding	IBA IDA	20074556
hormone activity	IEA
signaling receptor binding	TAS	8524787

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

G protein-coupled receptor binding [inference]

adrenomedullin receptor binding

receptor ligand activity [inference]

hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 22 in total

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2

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Next ›

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DO ID	Disease Name	Source
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10824	malignant hypertension	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:13603	obstructive jaundice	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2018	hyperinsulinism	Alliance of Genome Resources

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