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adrenomedullin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

133

PubChem

133

Alliance of Genome Resources

HGNC:259

Annotation

Keyword

3D-structure
Amidation
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Hormone
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35318

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 50 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor internalization	IDA	10882736
regulation of systemic arterial blood pressure	IDA	18434369
regulation of systemic arterial blood pressure	IBA
inflammatory response	TAS	8524787
signal transduction	TAS	10822232

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

metabolic process [inference]

hormone metabolic process [inference]

androgen metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

androgen metabolic process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

adrenomedullin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

cell population proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

negative regulation of vascular permeability

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

renal system process [inference]

regulation of urine volume

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

embryonic morphogenesis [inference]

branching involved in labyrinthine layer morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

spongiotrophoblast layer development

regeneration [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

growth [inference]

developmental growth

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

inflammatory response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

cellular response to stress [inference]

neuron projection regeneration

response to starvation

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

response to yeast

defense response to fungus [inference]

antifungal humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

defense response to fungus [inference]

antifungal humoral response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to ether

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

G protein-coupled receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

adrenomedullin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of cell population proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of the force of heart contraction

regulation of heart rate [inference]

positive regulation of heart rate

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of hormone biosynthetic process [inference]

positive regulation of hormone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

regulation of progesterone biosynthetic process [inference]

positive regulation of progesterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

regulation of vascular permeability [inference]

negative regulation of vascular permeability

regulation of body fluid levels [inference]

regulation of urine volume

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	10225288 12379507
extracellular space	IBA
cytoplasm	IDA	12379507
secretory granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	TAS	8524787
hormone activity	IDA	32296767
adrenomedullin receptor binding	IDA	20074556
adrenomedullin receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

G protein-coupled receptor binding [inference]

adrenomedullin receptor binding

receptor ligand activity [inference]

hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adrenomedullin

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adrenomedullin receptor binding
adrenomedullin receptor signaling pathway
hormone activity
positive regulation of heart rate
regulation of systemic arterial blood pressure

Displaying **all 2** entries
InterPro
Calcitonin/adrenomedullin
Pro-adrenomedullin

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 56 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100444764	PONAB02450
Ailuropoda melanoleuca	100473684	AILME15921
Nomascus leucogenys	100592483	NOMLE10835
Loxodonta africana	100665691	LOXAF12545
Cavia porcellus	100733203	CAVPO18991
Cricetulus griseus	100760129	CRIGR17786
Sarcophilus harrisii	100917278	SARHA07083
Otolemur garnettii	100963971	OTOGA19300
Pan paniscus	100984565	PANPA06174
Papio anubis	101008454	PAPAN07357

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements