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Guidelines

MIRAGE

deoxyribonuclease II alpha

Summary

Gene Symbol

Dnase2a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13423

PubChem

13423

Alliance of Genome Resources

MGI:1329019

Annotation

Keyword

Apoptosis
Developmental protein
Disulfide bond
Endonuclease
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
D3Z512	Acid DNase Deoxyribonuclease II alpha Lysosomal DNase II
P56542	Acid DNase Deoxyribonuclease II alpha Lysosomal DNase II
Q3UM14	Acid DNase Deoxyribonuclease II alpha Lysosomal DNase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA catabolic process	IMP	15568025 18991290
apoptotic DNA fragmentation	IBA
apoptotic process	IEA
enucleate erythrocyte differentiation	IMP	11375492
regulation of immune response	IGI	26371324

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of response to stimulus [inference]

regulation of immune response

Displaying 1 entry
GO Term	Evidence Code	PMID
lysosome	TAS	11375492

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA endonuclease activity	ISO
endodeoxyribonuclease activity	ISO
deoxyribonuclease II activity	IDA	11375492
deoxyribonuclease II activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Deoxyribonuclease-2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
deoxyribonuclease II activity
hydrolase activity

Displaying 1 entry
InterPro
Deoxyribonuclease II

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 8, 2025