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desmoglein 2

Summary

Gene Symbol

Dsg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13511

PubChem

13511

Alliance of Genome Resources

MGI:1196466

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O55111

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
desmosome organization	IEA ISO
response to progesterone	IEA
regulation of heart rate by cardiac conduction	IEA ISO
homophilic cell adhesion via plasma membrane adhesion molecules	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

homotypic cell-cell adhesion [inference]

cardiac muscle cell-cardiac muscle cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

heterotypic cell-cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell-cell junction organization [inference]

desmosome organization

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development [inference]

ventricular cardiac muscle tissue development [inference]

Purkinje myocyte development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to progesterone

response to lipid [inference]

response to steroid hormone [inference]

response to progesterone

response to ketone [inference]

response to progesterone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to progesterone

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell junction	ISO
desmosome	IBA IDA ISO	12631242 14673151 15775979 22274697 9864371
lateral plasma membrane	IEA ISO
apical plasma membrane	IEA ISO
intracellular membrane-bounded organelle	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

lateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

desmosome

cell-cell contact zone [inference]

intercalated disc

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA IEA
cell adhesion molecule binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Reverse transcriptase, RNase H-like domain

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Catenin binding domain superfamily
Desmosomal cadherin

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0060036	intrinsic cardiomyopathy	Alliance of Genome Resources
DOID:0110081	arrhythmogenic right ventricular dysplasia 10	Alliance of Genome Resources
DOID:0110458	dilated cardiomyopathy 1BB	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **118** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pongo abelii	100456327			PONAB13505
Ailuropoda melanoleuca	100468942			AILME05104
Danio rerio	100534918		ZFIN:ZDB-GENE-091204-215
Anolis carolinensis	100565052			ANOCA17439
Nomascus leucogenys	100579910			NOMLE29255
Sus scrofa	100625833			PIGXX29928
Loxodonta africana	100657228			LOXAF18525
Cavia porcellus	100736231	10141_0:0035e3
Sarcophilus harrisii	100922180			SARHA02438
Otolemur garnettii	100956043			OTOGA16242

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements