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beta-1,3-glucuronyltransferase 2

Summary

Gene Symbol

B3GAT2

Aliases

GlcAT-S
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
glucuronosyltransferase S

Organism

Homo sapiens (human)

External Links

NCBI Gene

135152

GGDB ID

gg156

HGNC

922

mRNA

NM_080742

map

6q13

Protein

NP_542780

OMIM

607497

KEGG Gene ID

hsa:135152

PubChem

135152

Alliance of Genome Resources

HGNC:922

Annotation

Keyword

3D-structure
Glycoprotein
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NPZ5	Beta-1,3-glucuronyltransferase 2 GlcAT-D UDP-glucuronosyltransferase S

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IBA
chondroitin sulfate proteoglycan biosynthetic process	IBA
protein glycosylation	IEA
carbohydrate biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

carbohydrate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

carbohydrate biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA ISS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity [inference]

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity [inference]

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg156

Gene Symbol

B3GAT2

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcA	G00055MO	G10271ZL	15470230

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcA	G00055MO	G10271ZL	15470230

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_072131	NM_022609
Mus musculus	NP_742122	NM_172124

KEGG BRITE Database

Orthology

K10157

Name

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]

References

Rhea

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.135

PMID

18400750

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.135

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2452	thrombophilia	DisGeNET
DOID:5419	schizophrenia	DisGeNET Alliance of Genome Resources
DOID:9206	Barrett's esophagus	DisGeNET Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Astyanax mexicanus	103033187		ASTMX06587
Ictalurus punctatus	108263352		ICTPU26767
Electrophorus electricus	113585462		ELEEL35443
Salmo salar	106576988		SALSA58074
Salmo trutta	115153208		SALTR08639
Salmo trutta	115193783		SALTR90574
Gadus morhua	115560220		GADMO15604
Oreochromis niloticus	100706305		ORENI13127
Sparus aurata	115597186		SPAAU10169
Xenopus laevis	733177	Xenbase:XB-GENE-921709

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024