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carboxypeptidase E

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1363

PubChem

1363

Alliance of Genome Resources

HGNC:2303

Annotation

Keyword

Alternative splicing
Carboxypeptidase
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disease variant
Glycoprotein
Hypogonadotropic hypogonadism
Intellectual disability
Membrane
Metal-binding
Metalloprotease
Obesity
Reference proteome
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P16870	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase
A0A384N679	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
insulin processing	IEA
cardiac left ventricle morphogenesis	IMP	19593212
neuropeptide signaling pathway	NAS	2334405
peptide hormone secretion	IEA
peptide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

insulin processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

macromolecule modification [inference]

protein modification process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide hormone processing [inference]

insulin processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

organic substance transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
secretory granule membrane	IEA
transport vesicle membrane	IEA
Golgi apparatus	IDA	19166515
plasma membrane	TAS	9019408
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	32814053
zinc ion binding	IEA
neurexin family protein binding	IPI	19166515
metallocarboxypeptidase activity	IBA
carboxypeptidase activity	TAS	9019408

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

neurexin family protein binding

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Carboxypeptidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
metallocarboxypeptidase activity
peptide metabolic process
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Carboxypeptidase-like, regulatory domain superfamily
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:11981	morbid obesity	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12876		MGI:101932	MOUSE58682
Rattus norvegicus	25669		RGD:2394	RATNO11191
Caenorhabditis elegans	177940		WB:WBGene00001189
Caenorhabditis elegans	181684		WB:WBGene00012073
Bos taurus	280753			BOVIN09016
Danio rerio	407979		ZFIN:ZDB-GENE-090313-68	DANRE16565
Ovis aries	443028			SHEEP07098
Pan troglodytes	461592	9598_0:00155b		PANTR34761
Macaca mulatta	708881			MACMU37205
Monodelphis domestica	100021886			MONDO28111

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements