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VPS37A subunit of ESCRT-I

Summary

Gene Symbol

VPS37A

Organism

Homo sapiens (human)

External Links

NCBI Gene

137492

PubChem

137492

Alliance of Genome Resources

HGNC:24928

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Endosome
Hereditary spastic paraplegia
Membrane
Nucleus
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NEZ2	ESCRT-I complex subunit VPS37A Hepatocellular carcinoma-related protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA IC IMP	20654576 21757351
multivesicular body assembly	NAS TAS	20588296 32424346
membrane fission	NAS	32424346
viral budding via host ESCRT complex	TAS	20588296
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	32424346

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

endosome organization [inference]

multivesicular body organization [inference]

multivesicular body assembly

organelle assembly [inference]

multivesicular body assembly

cellular component assembly [inference]

organelle assembly [inference]

multivesicular body assembly

membrane organization [inference]

membrane fission

viral process [inference]

viral budding [inference]

viral budding via host ESCRT complex

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
nucleoplasm	IDA
late endosome membrane	IEA
endosome membrane	NAS TAS	32424346
ESCRT I complex	IBA IDA IPI ISS TAS	18005716 20588296 20654576 21757351

GO Hierarchy

cellular component

protein-containing complex [inference]

ESCRT complex [inference]

ESCRT I complex

membrane protein complex [inference]

ESCRT I complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

bounding membrane of organelle [inference]

endosome membrane

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32296183 32814053 33961781 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vacuolar sorting protein

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
protein targeting to membrane
protein targeting to vacuole
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Displaying **all 3** entries
InterPro
ESCRT assembly domain
Helix hairpin bin domain superfamily
Modifier of rudimentary, Modr

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110805	hereditary spastic paraplegia 53	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31006		FB:FBgn0016038
Mus musculus	52348		MGI:1261835	MOUSE60155
Rattus norvegicus	290775		RGD:1560016	RATNO11210
Danio rerio	336368		ZFIN:ZDB-GENE-030131-8312	DANRE49918
Pan troglodytes	472921	9598_0:00241b		PANTR42026
Canis lupus familiaris	475611			CANLF04751
Bos taurus	513985			BOVIN22005
Xenopus tropicalis	548736		Xenbase:XB-GENE-969334
Macaca mulatta	710187			MACMU43502
Xenopus laevis	734384		Xenbase:XB-GENE-969339

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements