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exostosin glycosyltransferase 2

Summary

Gene Symbol

Ext2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14043

KEGG Gene ID

mmu:14043

PubChem

14043

Alliance of Genome Resources

MGI:108050

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P70428	Exostosin glycosyltransferase 2 Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Multiple exostoses protein 2 homolog
Q3UDB5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
sulfation	IDA	18337501
protein N-linked glycosylation	IDA	18337501
mesoderm formation	IMP	16236767
sodium ion homeostasis	IGI	31365577
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

sulfur compound biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

sulfur compound biosynthetic process [inference]

sulfation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

sulfur compound biosynthetic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin biosynthetic process

sulfur compound biosynthetic process [inference]

sulfation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

heparin biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

gene expression

sulfur compound biosynthetic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

multicellular organismal process [inference]

ossification

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis [inference]

endochondral bone morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

sodium ion homeostasis

inorganic ion homeostasis [inference]

sodium ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to fibroblast growth factor stimulus

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to fibroblast growth factor stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IBA IDA ISO	10639137
Golgi membrane	IC	10639137

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

UDP-N-acetylglucosamine transferase complex

endoplasmic reticulum protein-containing complex [inference]

UDP-N-acetylglucosamine transferase complex

catalytic complex

UDP-N-acetylglucosamine transferase complex

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
glycosyltransferase activity	ISO
heparan sulfate N-acetylglucosaminyltransferase activity	IC	10639137
transferase activity	IEA
protein homodimerization activity	IDA	10639137
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IC IGI ISO	10639137

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K02367

Name

glucuronyl/N-acetylglucosaminyl transferase EXT2 [EC:2.4.1.224 2.4.1.225]

References

9756849

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R10138	2.4.1.225	G18844FT	G70244WB
R05935	2.4.1.225	G13581JW	G74553IH

Rhea

RHEA:16213

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.224

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:206	hereditary multiple exostoses	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3772101	FB:FBgn0029175
Callorhinchus milii	103174976		CALMI06700
Latimeria chalumnae	102363354		LATCH19706
Danio rerio	493780	ZFIN:ZDB-GENE-041124-3	DANRE40872
Astyanax mexicanus	103046596		ASTMX15320
Ictalurus punctatus	108271344		ICTPU00780
Electrophorus electricus	113575759		ELEEL14078
Salmo trutta	115167097		SALTR82495
Gadus morhua	115558722		GADMO13348
Oryzias latipes	101163398		ORYLA12344

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements