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mucin 4

Summary

Gene Symbol

Muc4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

140474

PubChem

140474

Alliance of Genome Resources

MGI:2153525

Annotation

Keyword

Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8JZM8	Ascites sialoglycoprotein Pancreatic adenocarcinoma mucin Testis mucin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
negative regulation of cell-cell adhesion	ISO
maintenance of gastrointestinal epithelium	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of response to tumor cell [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of T cell mediated cytotoxicity directed against tumor cell target [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity directed against tumor cell target

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
microvillus membrane	ISO
extracellular space	IBA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

microvillus membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein-containing complex binding	ISO
ErbB-2 class receptor binding	IBA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

ErbB-2 class receptor binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

mucin-4

Functional Category

F: Nucleotide transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 2** entries
Gene Ontology
ErbB-2 class receptor binding
cell-matrix adhesion

Disease

Disease Ontology

Displaying entries **11 - 13** of 13 in total

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DO ID	Disease Name	Source
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4608	common bile duct neoplasm	Alliance of Genome Resources
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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2

3

4

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4585		HGNC:7514
Rattus norvegicus	303887	10116_1:003ba0	RGD:621331
Xenopus tropicalis	100485162		Xenbase:XB-GENE-852599
Cavia porcellus	100724323	10141_0:00414b
Cricetulus griseus	100763347	10029_0:002cd5
Octodon degus	101565864	10160_0:004297
Heterocephalus glaber	101700798	10181_0:000148
Mesocricetus auratus	101843758	10036_0:002003
Ictidomys tridecemlineatus	101976964	43179_0:00310a
Microtus ochrogaster	102001309	79684_0:0005c2

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Last updated: December 9, 2024